Evidence map›Paper›PMID 40502780›Full record

ArticleResearch square2025

tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in

Nicholas S Galambos, Olivia J Crocker, Blair K Schneider, Kennelly S Allerton, Katrin E Gross, Alexandra E Schneider, Jared Lynch, Onur Yukselen, Alper Kucukural, Colin C Conine

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Nicholas S GalambosDivision of Neonatology, Children's Hospital of Philadelphia. Philadelphia, PA, USA.
Olivia J CrockerDivision of Neonatology, Children's Hospital of Philadelphia. Philadelphia, PA, USA.
Blair K SchneiderDivision of Neonatology, Children's Hospital of Philadelphia. Philadelphia, PA, USA.
Kennelly S AllertonDepartments of Genetics and Pediatrics - Penn Epigenetics Institute, Institute of Regenerative Medicine, and Center for Women's Health and Reproduction Medicine, University of Pennsylvania Perelman School of Medicine. Philadelphia, PA, USA.
Katrin E GrossDivision of Neonatology, Children's Hospital of Philadelphia. Philadelphia, PA, USA.
Alexandra E SchneiderDivision of Neonatology, Children's Hospital of Philadelphia. Philadelphia, PA, USA.
Jared LynchDepartments of Genetics and Pediatrics - Penn Epigenetics Institute, Institute of Regenerative Medicine, and Center for Women's Health and Reproduction Medicine, University of Pennsylvania Perelman School of Medicine. Philadelphia, PA, USA.
Onur YukselenDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Alper KucukuralDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-9983-394X
Colin C ConineDivision of Neonatology, Children's Hospital of Philadelphia. Philadelphia, PA, USA.ORCID 0000-0001-7915-0463

Funding

University of Pennsylvania Postdoctoral Opportunities in Research and TeachingK12GM081259 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Janis K. Burkhardt · 2007 to 2026
$20.1M
Developing C. elegans as a model to understand tRNA-fragment biogenesis and functionR35GM151087 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Colin Conine · 2023 to 2026
$1.8M
NIGMS NIH HHS K12 GM081259NIGMS NIH HHS R35 GM151087
6 · The paper itself

Abstract

The environment encountered by an organism can modulate epigenetic information in gametes to transmit non-genetically inherited phenotypes to offspring. In mouse models, the diet of males regulates specific tRNA-derived RNAs (tDRs) in sperm. After fertilization, tDRs regulate embryonic gene expression and generate metabolic phenotypes in adult offspring through uncharacterized changes during development. Here we demonstrate that in

Identifiers

PMID40502780
PMCPMC12155203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.