Evidence map›Paper›PMID 40502778›Full record

ArticleResearch square2025

Automated Real-time Assessment of Intracranial Hemorrhage Detection AI Using an Ensembled Monitoring Model (EMM).

Zhongnan Fang, Andrew Johnston, Lina Cheuy, Hye Sun Na, Magdalini Paschali, Camila Gonzalez, Bonnie A Armstrong, Arogya Koirala, Derrick Laurel, Andrew Walker Campion and 3 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Zhongnan FangDepartment of Radiology, School of Medicine, Stanford University.
Andrew JohnstonDepartment of Radiology, School of Medicine, Stanford University.
Lina CheuyDepartment of Radiology, School of Medicine, Stanford University.
Hye Sun NaDepartment of Radiology, School of Medicine, Stanford University.
Magdalini PaschaliDepartment of Radiology, School of Medicine, Stanford University.
Camila GonzalezDepartment of Radiology, School of Medicine, Stanford University.
Bonnie A ArmstrongDepartment of Radiology, School of Medicine, Stanford University.
Arogya KoiralaDepartment of Radiology, School of Medicine, Stanford University.
Derrick LaurelDepartment of Radiology, School of Medicine, Stanford University.
Andrew Walker CampionDepartment of Radiology, School of Medicine, Stanford University.
Michael IvDepartment of Radiology, School of Medicine, Stanford University.
Akshay S ChaudhariDepartment of Radiology, School of Medicine, Stanford University.
David B LarsonDepartment of Radiology, School of Medicine, Stanford University.

Funding

Rapid MRI for Evaluation of OsteoarthritisR01EB002524 · NIBIB · STANFORD UNIVERSITY · PI Akshay Chaudhari, Garry E Gold · 2003 to 2026
$10.1M
TR&D Project 3: OpenSim for PredictionP41EB027060 · NIBIB · STANFORD UNIVERSITY · PI SCOTT L DELP · 2020 to 2026
$9.7M
RADX TECH - CERES NANOSCIENCE INC NANOTRAP PARTICLE MANUFACTURING75N92020C00021 · NHLBI · CERES NANOSCIENCES, LLLP · PI DUNLAP, ROSS · 2021 to 2021
$4.0M
Rapid Low-Cost Quantitative 3D MRI and Gait Assessment of the KneeR01AR077604 · NIAMS · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2020 to 2024
$3.2M
Imaging of Joint Response to Physiological Stress with Age, Sex and in OsteoarthritisR01AR079431 · NIAMS · STANFORD UNIVERSITY · PI Feliks Kogan · 2022 to 2026
$2.9M
Opportunistic Atherosclerotic Cardiovascular Disease Risk Estimation at Abdominal CTs with Robust and Unbiased Deep LearningR01HL167974 · NHLBI · STANFORD UNIVERSITY · PI Imon Banerjee, Akshay Chaudhari · 2023 to 2026
$2.4M
Novel Incidental Calcium Evaluation (NICE)R01HL169345 · NHLBI · STANFORD UNIVERSITY · PI Imon Banerjee, Akshay Chaudhari · 2024 to 2026
$2.1M
NHLBI NIH HHS 75N92020C00008NHLBI NIH HHS 75N92020C00021NHLBI NIH HHS R01 HL167974NHLBI NIH HHS R01 HL169345NIAMS NIH HHS R01 AR077604NIAMS NIH HHS R01 AR079431NIBIB NIH HHS P41 EB027060NIBIB NIH HHS R01 EB002524
6 · The paper itself

Abstract

Artificial intelligence (AI) tools for radiology are commonly unmonitored once deployed. The lack of real-time case-by-case assessments of AI prediction confidence requires users to independently distinguish between trustworthy and unreliable AI predictions, which increases cognitive burden, reduces productivity, and potentially leads to misdiagnoses. To address these challenges, we introduce Ensembled Monitoring Model (EMM), a framework inspired by clinical consensus practices using multiple expert reviews. Designed specifically for black-box commercial AI products, EMM operates independently without requiring access to internal AI components or intermediate outputs, while still providing robust confidence measurements. Using intracranial hemorrhage detection as our test case on a large, diverse dataset of 2919 studies, we demonstrate that EMM successfully categorizes confidence in the AI-generated prediction, suggesting different actions and helping improve the overall performance of AI tools to ultimately reduce cognitive burden. Importantly, we provide key technical considerations and best practices for successfully translating EMM into clinical settings.

Identifiers

PMID40502778
PMCPMC12154145

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.