Evidence map›Paper›PMID 40502774›Full record

ArticleResearch square2025

Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair.

Paul Robbins, Lei Zhang, Osama Elsallabi, Carolina Soto-Palma, Josh Bartz, Rahagir Salekeen, Allancer Nunes, Wandi Xu, Kyooa Lee, Brian Hughes and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Paul RobbinsUniversity of Minnesota.ORCID 0000-0003-1068-7099
Lei ZhangUniversity of Minnesota.ORCID 0000-0001-7409-6090
Osama ElsallabiUniversity "G. d'Annunzio" of Chieti-Pescara.
Carolina Soto-PalmaUniversity of Minnesota.
Josh BartzUniversity of Minnesota.
Rahagir SalekeenUniversity of Minnesota.
Allancer NunesUniversity of Minnesota.
Wandi XuUniversity of Minnesota.ORCID 0009-0009-4984-0004
Kyooa LeeUniversity of Minnesota.
Brian HughesUniversity of Minnesota.
Borui ZhangUniverrsity of Minnesota.
Abdalla MohamedUniversity of Minnesota.
Sara McGowanInstitute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota.ORCID 0009-0004-5648-0848
Luise AngeliniInstitute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota.
Ryan O'KellyInstitute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota.
Seyed Ali BiashadUniversity of Rochester.
Eric HillpotUniversity of Rochester.
Francesco MorandiniUniversity of Rochester.ORCID 0000-0003-1040-8539
Andrei SeluanovUniversity of Rochester.
Vera GorbunovaUniversity of Rochester.
Xiao DongUniversity of Minnesota.ORCID 0000-0001-9987-5760
Laura NiedernhoferUniversity of Minnesota.ORCID 0000-0002-1074-1385

Funding

The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2014 to 2026
$36.9M
Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4M
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7M
Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5M
Midwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5M
PROTEOMICSP01AG043376 · NIA · UNIVERSITY OF MINNESOTA · PI ROBBINS, PAUL D. · 2013 to 2019
$11.2M
Minnesota Tissue Mapping Center for Senescent CellsU54AG076041 · NIA · UNIVERSITY OF MINNESOTA · PI LAURA Jane NIEDERNHOFER · 2021 to 2026
$10.5M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
The role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2M
Regulation of epigenome stability by SIRT6 during aging. Supplement: Does centenarian variant of SIRT6 or bowhead whale SIRT6 confer protection from Alzheimer's disease?R37AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2019 to 2026
$4.7M
Using the senolytic fisetin to suppress mortality in aged mice acutely exposed to murine beta-coronavirusR01AG063543 · NIA · UNIVERSITY OF MINNESOTA · PI NIEDERNHOFER, LAURA JANE · 2019 to 2023
$3.4M
Regulation of genome stability by SITR6R01AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI SELUANOV, ANDREI · 2014 to 2018
$1.9M
NIA NIH HHS P01 AG043376NIA NIH HHS P01 AG047200NIA NIH HHS P01 AG051449NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG027237NIA NIH HHS R01 AG046320NIA NIH HHS R01 AG063543NIA NIH HHS R01 AG069819NIA NIH HHS R37 AG046320NIA NIH HHS T32 AG029796NIA NIH HHS U19 AG056278NIA NIH HHS U54 AG076041NIA NIH HHS U54 AG079754
6 · The paper itself

Abstract

Aging is marked by the accumulation of senescent cells (SnCs), which contribute to tissue dysfunction and age-related diseases. Senotherapeutics, including senolytics which specifically induce lysis of SnCs and senomorphics, which suppress the senescence phenotype, represent promising therapeutic interventions for mitigating age-related pathologies and extending healthspan. Using a phenotypic-based senescent cell screening assay, we identified fucoidans, a class of sulfated polysaccharides derived from brown algae and seaweed, as novel senotherapeutics. In particular, fucoidan from

Indexed as

agingDNA repairfucoidanhealthspanNHEJseaweedsenescencesenolyticsenomorphicsenotherapeuticSIRT6

Identifiers

PMID40502774
PMCPMC12155233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.