ArticleResearch square2025
NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas.
Nishanth S Sadagopan, Mateo Gomez, Shashwat Tripathi, Leah K Billingham, Susan L DeLay, Martha A Cady, Harrshavasan T S Congivaram, Tzu-Yi Chia, Hanxiao Wan, Si Wang and 8 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
18 authors.
Nishanth S SadagopanNorthwestern University Feinberg School of Medicine.
Mateo GomezNorthwestern University Feinberg School of Medicine.
Shashwat TripathiNorthwestern University Feinberg School of Medicine.
Leah K BillinghamNorthwestern University Feinberg School of Medicine.
Susan L DeLayNorthwestern University Feinberg School of Medicine.
Martha A CadyUniversity of California.
Harrshavasan T S CongivaramNorthwestern University Feinberg School of Medicine.
Tzu-Yi ChiaNorthwestern University Feinberg School of Medicine.
Hanxiao WanNorthwestern University Feinberg School of Medicine.
Si WangNorthwestern University Feinberg School of Medicine.
David R RaleighUniversity of California.
Faith C KalubaVan Andel Institute.
Evan C LienVan Andel Institute.
Amy B HeimbergerNorthwestern University Feinberg School of Medicine.
Catalina Lee-ChangNorthwestern University Feinberg School of Medicine.
Mark W YoungbloodNorthwestern University Feinberg School of Medicine.
Stephen T MagillNorthwestern University Feinberg School of Medicine.
Jason M MiskaNorthwestern University Feinberg School of Medicine.
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MProject 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang, Janine Marie Lupo · 2007 to 2026
$44.7MSTINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBMP50CA221747 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Atique U. Ahmed · 2018 to 2026
$21.4MUnderstanding druggable drivers of meningioma tumorigenesisR01CA262311 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RALEIGH, DAVID R · 2021 to 2025
$2.7MThe hypoxic niche in glioblastoma is maintained by myeloid produced creatineR01CA279686 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jason Miska · 2023 to 2026
$1.5MNCI NIH HHS P01 CA118816NCI NIH HHS P30 CA060553NCI NIH HHS P50 CA221747NCI NIH HHS R01 CA262311NCI NIH HHS R01 CA279686
6 · The paper itselfAbstract
purpose
methodsWe performed single-cell RNA sequencing on NOTCH3 + human meningioma cell lines. Using the CH157-MN meningioma cell model, we overexpressed
resultsWe show that
conclusionThese data establish a link between
Indexed as
Fatty Acid OxidationFerroptosisMeningioma MetabolismNOTCH3Tumor Microenvironment
Identifiers
PMID40502769
PMCPMC12155216
What OpenQuestion holds
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