Evidence map›Paper›PMID 40502764›Full record

ArticleResearch square2025

Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation.

Kay Tye, Caroline Jia, Andrea Tran, Faith Aloboudi, Ella Say, Nick Thao, Christopher Lee, Kanha Batra, Amanda Nguyen, Aneesh Bal and 11 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kay TyeSalk Institute for Biological Studies.ORCID 0000-0002-2435-0182
Caroline JiaSalk Institute for Biological Studies.
Andrea TranSalk Institute for Biological Studies.
Faith AloboudiSalk Institute for Biological Studies.
Ella SaySalk Institute for Biological Studies.ORCID 0009-0008-9313-1291
Nick ThaoSalk Institute for Biological Studies.
Christopher LeeSalk Institute for Biological Studies.
Kanha BatraThe Salk Institute for Biological Studies.ORCID 0000-0001-6401-4274
Amanda NguyenSalk Institute for Biological Studies.
Aneesh BalSalk Institute.
Jeremy DelahantySalk Institute for Biological Studies.
May ChanSalk Institute for Biological Studies.
Laurel KeyesHoward Hughes Medical Institute.ORCID 0000-0001-5433-9948
Reesha PatelFeinberg School of Medicine.
Romy WichmannSalk Institute.ORCID 0000-0002-4506-8813
Felix TaschbachSalk Institute.ORCID 0000-0001-5345-5787
Yulong LiPeking University.ORCID 0000-0002-9166-9919
Marcus BennaUniversity of California, San Diego.ORCID 0000-0001-8100-2857
Talmo PereiraSalk Institute for Biological Studies.ORCID 0000-0001-9075-8365
Hao LiSalk Institute.ORCID 0000-0001-8710-1290
Nathaniel NonoSalk Institute for Biological Studies.

Funding

Neural Circuit Mechanisms of Social Homeostasis in Individuals and Supraorganismal Social GroupsDP1AT009925 · NCCIH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TYE, KAY MAXINE · 2017 to 2021
$6.4M
Solving the Valence Assignment ProblemR37MH102441 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Kay Maxine Tye · 2021 to 2026
$5.6M
cloudSLEAP: Maximizing accessibility to deep learning-based motion captureRF1MH132653 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PEREIRA, TALMO D. · 2023 to 2023
$2.6M
Exploring neural circuit mechanisms of social contact and social isolationR01MH115920 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TYE, KAY MAXINE · 2018 to 2022
$2.4M
Understanding the role of paraventricular neurotensin neurons in valence processingR00DA055111 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hao Li · 2024 to 2026
$827k
NCCIH NIH HHS DP1 AT009925NIDA NIH HHS R00 DA055111NIMH NIH HHS R01 MH115920NIMH NIH HHS R37 MH102441NIMH NIH HHS RF1 MH132653
6 · The paper itself

Abstract

The "Pain Overlap Theory"

Identifiers

PMID40502764
PMCPMC12155228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.