Evidence map›Paper›PMID 40502757›Full record

ArticleResearch square2025

Phosphorylation State Dictates Bacterial Stressosome Assembly and Function.

Elizabeth A Martinez-Bond, Ivanna Lopez-Ayala, Mariya Lobanovska, Lisa Qiu, Virginia Garda, Zanlin Yu, Daniel A Portnoy, Allison H Williams

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elizabeth A Martinez-BondDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
Ivanna Lopez-AyalaDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
Mariya LobanovskaDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.
Lisa QiuDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.ORCID https://orcid.org/0009-0002-0133-7556
Virginia GardaDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
Zanlin YuDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.ORCID https://orcid.org/0000-0001-8381-8788
Daniel A PortnoyDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.
Allison H WilliamsDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0002-0726-141X

Funding

Atomic-level probing of the peptidoglycan biosynthetic machinery in bacterial cell wall biogenesisR01GM144694 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VERBA, KLIMENT A · 2022 to 2025
$1.6M
NIGMS NIH HHS R01 GM144694
6 · The paper itself

Abstract

Bacterial pathogens rely on their ability to sense and respond to environmental stressors to survive and maintain virulence. The stressosome, a 1.8-megadalton nanomachine, serves as a critical sensor and regulator of the general stress response. It is composed of multiple copies of three proteins RsbR, RsbS, and the kinase RsbT which together orchestrate activation of downstream stress adaptation pathways. Using cryo-electron microscopy, we solved the atomic structure of five

Identifiers

PMID40502757
PMCPMC12154155

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.