Evidence map›Paper›PMID 40502707›Full record

ArticleiScience2025

Telomere attrition alters extracellular vesicles conferring adverse impacts on neuronal viability and inflammatory response.

Yi Gong, Yunong Wang, Francheska Delgado-Peraza, Carlos Nogueras-Ortiz, Nicole Noren Hooten, Deborah L Croteau, Mithlesh Temre, Abigail E Molnar, Monica Bodogai, Ainslee Zou and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yi GongLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Yunong WangLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Francheska Delgado-PerazaLaboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Carlos Nogueras-OrtizLaboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Nicole Noren HootenLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Deborah L CroteauLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Mithlesh TemreLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Abigail E MolnarLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Monica BodogaiLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Ainslee ZouLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Kotb AbdelmohsenLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Wei ZhuLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Yongqing ZhangLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Myriam GorospeLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Nan-Ping WengLaboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Dimitrios KapogiannisLaboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Yie LiuLaboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomere shortening is a hallmark of aging associated with various diseases, yet its impact on extracellular vesicles (EVs) remains poorly understood. We investigated EV abundance, size, cargo content, and functional implications in a human aging cohort and the telomerase reverse transcriptase null (

Indexed as

Cell biologyImmunologyNeuroscience

Identifiers

PMID40502707
PMCPMC12158500

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.