Evidence map›Paper›PMID 40502700›Full record

ArticleiScience2025

LCN2-mediated ferroptosis resistance in tissue homeostasis and early-stage tumorigenesis of the fallopian tube epithelium.

Keiyo Imaeda, Tomohiro Tamura, Shimpei Nagai, Eiji Sugihara, Juntaro Yamasaki, Yuji Otsuki, Kohei Nakamura, Takashi Takeda, Kanako Nakamura, Yuya Nogami and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Keiyo ImaedaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Tomohiro TamuraDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Shimpei NagaiDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Eiji SugiharaDivision of Gene Regulation, Oncology Innovation Center, Fujita Health University, Toyoake, Japan.
Juntaro YamasakiDivision of Gene Regulation, Oncology Innovation Center, Fujita Health University, Toyoake, Japan.
Yuji OtsukiDivision of Gene Regulation, Oncology Innovation Center, Fujita Health University, Toyoake, Japan.
Kohei NakamuraCenter for Cancer Genomics, Keio University School of Medicine, Tokyo, Japan.
Takashi TakedaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Kanako NakamuraDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Yuya NogamiDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Kosuke TsujiDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Tatsuyuki ChiyodaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Iori KisuDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Yusuke KobayashiDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Kouji BannoDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Rui YamaguchiDivision of Cancer Systems Biology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Kazuhiro SakuradaDepartment of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine, Tokyo, Japan.
Hideyuki SayaDivision of Gene Regulation, Oncology Innovation Center, Fujita Health University, Toyoake, Japan.
Daisuke AokiDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Ahmed Ashour AhmedOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Osamu NaganoDivision of Gene Regulation, Oncology Innovation Center, Fujita Health University, Toyoake, Japan.
Kenta MasudaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Wataru YamagamiDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the fallopian tube epithelium (FTE) is known to be composed of various differentiated cells such as secretory and ciliated cells, the upstream regulatory mechanisms of cell differentiation that are essential for tissue homeostasis remain under investigation. In this study, we established human FTE organoids and identified quiescent cells within the early organoid formation by observing cellular proliferation heterogeneity. We also analyzed two single-cell transcriptomic data to trace the differentiation trajectory in human FTE, and found that the gene

Indexed as

Cell biologyOmicsTissue Engineering

Identifiers

PMID40502700
PMCPMC12158494

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.