Evidence map›Paper›PMID 40502695›Full record

ArticleiScience2025

Oncostatin M is dispensable for the regulation of hematopoietic stem/progenitor cell traffic by neutrophils.

Anna Rodella, Carlotta Boscaro, Francesco Ivan Amendolagine, Ludovica Migliozzi, Barbara Molon, Antonella Viola, Mattia Albiero, Gian Paolo Fadini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna RodellaVeneto Institute of Molecular Medicine, 35100 Padova, Padua, Italy.
Carlotta BoscaroVeneto Institute of Molecular Medicine, 35100 Padova, Padua, Italy.
Francesco Ivan AmendolagineVeneto Institute of Molecular Medicine, 35100 Padova, Padua, Italy.
Ludovica MigliozziVeneto Institute of Molecular Medicine, 35100 Padova, Padua, Italy.
Barbara MolonDepartment of Biomedical Sciences, University of Padova, 35128 Padua, Italy.
Antonella ViolaDepartment of Biomedical Sciences, University of Padova, 35128 Padua, Italy.
Mattia AlbieroVeneto Institute of Molecular Medicine, 35100 Padova, Padua, Italy.
Gian Paolo FadiniVeneto Institute of Molecular Medicine, 35100 Padova, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic stem/progenitor cell (HSPC) trafficking in and out of the bone marrow (BM) is essential for immune surveillance and hematopoietic balance. We previously identified Oncostatin M (OSM), primarily from myeloid cells, as a key regulator of HSPC traffic. Here, we show that neutrophils highly express and secrete OSM, especially when senesced. However, OSM is not required for neutrophil-mediated modulation of steady-state or circadian HSPC levels. Aged neutrophils returning to the BM reduce HSPC levels in peripheral blood (PB) independently of OSM, suggesting additional mechanisms beyond CXCL12/CXCR4 axis. While neutrophil transfer modulated HSPC kinetics in wild-type mice, OSM-secreting neutrophils failed to normalize elevated PB-HSPC levels in

Indexed as

Components of the immune systemImmunology

Identifiers

PMID40502695
PMCPMC12158506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.