ArticleiScience2025
Reciprocal regulation of Solo and Src orchestrates Src trafficking to promote mesenchymal cell migration.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- ESRP1 drives epithelial-mesenchymal transition by activating EPAC-RAP1A signaling axis.Frontiers in medicine · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rho GTPases are key regulators of cell motility and membrane trafficking, influencing critical processes such as epithelial-mesenchymal transition (EMT). Among them, the small GTPase RhoB plays a pivotal role, but the mechanisms underlying its regulation remain largely unclear. We have previously identified the Rho guanine nucleotide exchange factor (RhoGEF) Solo (ARHGEF40) as a regulator of endosomal RhoB in epithelial cells. Here, we find that Solo is upregulated in breast cancer cells with high EMT scores and promotes cell motility through its RhoGEF activity. Solo's ability to enhance migration is further regulated by phosphorylation at tyrosine 242, mediated by the proto-oncogene Src. By combining high-resolution imaging with photoconversion assays, we further demonstrate that Solo regulates Src trafficking dynamics, localization, and consequently signaling at focal adhesions. Together, our data identify Solo as a novel feedback regulator of Src and a key driver of the motility of breast cancer cells with mesenchymal characteristics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.