ArticlemedRxiv : the preprint server for health sciences2025
Vascular risk factors mediate the relationship between education and white matter hyperintensities.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionEducation can protect against cognitive decline and dementia through cognitive reserve and reduced vascular risk. This study examined whether vascular risk mediates the relationship between education and white matter hyperintensity (WMH) burden.
methodsData from 1089 older adults from the National Alzheimer's Coordinating Center were analyzed. A composite vascular score was created using diabetes, hypertension, hypercholesterolemia, smoking, alcohol abuse, body mass index, and blood pressure. Linear regressions and mediation analyses examined associations and indirect effects between education, vascular risk, and WMH, adjusting for age, sex, and diagnosis.
resultsHigher education was associated with lower vascular risk ( DISCUSSION: Education influences cerebrovascular health via reducing vascular risk. Addressing vascular health may reduce WMH burden.
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