Poor Sleep Health Early After Stroke is Associated with Lower Quality of Life Later After Stroke.

Background: Factors early after stroke that are predictive of outcomes can help guide rehabilitation interventions. There is a growing understanding of the importance of sleep for recovery after stroke. Objectives: To explore factors at 10 days post stroke, including sleep health (SH), that may be associated with QOL at 60 days post stroke. Methods: Data from 62 participants were collected at 10 and 60 days post stroke. Independent variables at 10 days post stroke were the NIHSS, Barthel Index (BI), Montreal Cognitive Assessment (MOCA), Patient Health Questionnaire (PHQ-9), gait speed, Berg Balance Scale, and SH. SH was measured by combining data from actigraphy and self-report to create a score that reflected regularity, satisfaction, alertness, timing, efficiency, and duration of sleep (S-Ru-SATED). The Stroke Impact Scale (SIS) at 60 days post stroke assessed quality of life. A multiple linear regression using a leave-one-out cross validation was employed to assess the association between the independent variables at 10 days and the SIS at 60 days. Results: The leave-one-out cross-validation analysis revealed that MOCA (p=0.0068), NIHSS (p=0.0181), BI (p=0.0028), and S-Ru-SATED (p=0.000155) at 10 days post stroke were significantly associated with the SIS at 60 days post stroke. Conclusions: Participants with less stroke severity, higher cognition, better functional ability, and better SH early after stroke were more likely to have a higher QOL at 2 months post stroke. Research is needed to assess the impact of interventions to improve SH in conjunction with rehabilitation interventions after stroke.