Evidence map›Paper›PMID 40502560›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Phylogenetic context of antibiotic resistance provides insights into the dynamics of resistance emergence and spread.

Kyle J Gontjes, Aryan Singh, Sarah E Sansom, James D Boyko, Stephen A Smith, Ebbing Lautenbach, Evan Snitkin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kyle J GontjesDepartment of Microbiology and Immunology, University of Michigan Medical School.ORCID 0000-0001-8671-7990
Aryan SinghDepartment of Microbiology and Immunology, University of Michigan Medical School.
Sarah E SansomDepartment of Internal Medicine, Division of Infectious Diseases, Rush University Medical Center.ORCID 0000-0002-1924-8941
James D BoykoDepartment of Ecology and Evolutionary Biology, University of Michigan.ORCID 0000-0003-0952-169X
Stephen A SmithDepartment of Ecology and Evolutionary Biology, University of Michigan.ORCID 0000-0003-2035-9531
Ebbing LautenbachCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine.
Evan SnitkinDepartment of Microbiology and Immunology, University of Michigan Medical School.ORCID 0000-0001-8409-278X

Funding

University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
The Michigan Infectious Disease Genomics (MIDGE) CenterU19AI181767 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAURING, ADAM, SNITKIN, EVAN · 2024 to 2024
$6.2M
Regional genomic epidemiology to identify drivers of resistance, transmission and infection with carbapenem-resistant Klebsiella pneumoniaeR01AI148259 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SNITKIN, EVAN · 2020 to 2023
$2.2M
Genome-driven identification of patient and bacterial drivers of resistance to novel beta-lactam/beta-lactamase inhibitor combination therapiesF31AI186288 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GONTJES, KYLE JAMES · 2024 to 2025
$84k
NHGRI NIH HHS T32 HG000040NIAID NIH HHS F31 AI186288NIAID NIH HHS R01 AI148259NIAID NIH HHS U19 AI181767
6 · The paper itself

Abstract

Background: To ameliorate the antibiotic resistance crisis, the drivers of resistance emergence (i.e., Methods: Whole-genome sequencing and susceptibility testing were performed on clinical carbapenem-resistant Results: Phylogenetic analysis of 386 epidemic lineage carbapenem-resistant Conclusions: Phylogenetic contextualization generated insights and hypotheses into how bacterial genetic background, patient characteristics, and clinical practices influence the emergence and spread of antibiotic resistance.

Indexed as

ancestral state reconstructionantibiotic resistanceclinical driversgenomic epidemiologyKlebsiella pneumoniaephylogeneticsrisk factor analysiswhole-genome sequencing

Identifiers

PMID40502560
PMCPMC12154989

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.