Evidence map›Paper›PMID 40502553›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Connectometry reveals differing associations of cortisol and PACAP with dorsal cingulum microstructure in posttraumatic stress.

Steven J Granger, Sydney A Jobson, Caitlin Ravichandran, Quentin Devignes, Eylül Akman, Jennifer U Blackford, Victor May, Sayamwong E Hammack, William A Carlezon, Kerry J Ressler and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Steven J GrangerDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.ORCID 0000-0003-4657-4897
Sydney A JobsonDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.
Caitlin RavichandranDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Quentin DevignesDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.ORCID 0000-0002-7544-6328
Eylül AkmanDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.
Jennifer U BlackfordMunroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.
Victor MayLarner College of Medicine, University of Vermont, Burlington, VT, USA.
Sayamwong E HammackLarner College of Medicine, University of Vermont, Burlington, VT, USA.
William A CarlezonDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Kerry J ResslerDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.ORCID 0000-0002-5158-1103
Scott L RauchDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.ORCID 0000-0001-7699-6754
Isabelle M RossoDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.ORCID 0000-0001-6988-3858

Funding

SPARED CenterP50MH115874 · NIMH · MCLEAN HOSPITAL · PI ROSSO, ISABELLE M · 2019 to 2023
$13.7M
PACAP and the Response to Stressors: Neural MechanismsR01MH097988 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HAMMACK, SAYAMWONG E., MAY, VICTOR · 2012 to 2023
$3.7M
Multimodal imaging of hippocampal-cortical networks and mechanisms of trauma-related intrusionsR01MH120400 · NIMH · MCLEAN HOSPITAL · PI ROSSO, ISABELLE M · 2019 to 2023
$3.3M
Progressive social withdrawal in trauma-exposed older adolescents and young adults: neurocircuitry predictorsR01MH125852 · NIMH · MCLEAN HOSPITAL · PI ROSSO, ISABELLE M · 2021 to 2025
$2.4M
NIMH NIH HHS P50 MH115874NIMH NIH HHS R01 MH097988NIMH NIH HHS R01 MH120400NIMH NIH HHS R01 MH125852Wellcome Trust
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) has been associated with altered arousal regulation and dysfunction of the hypothalamic-pituitary-adrenal axis, including changes in circulating cortisol and pituitary adenylate cyclaseactivating polypeptide (PACAP). Both stress-related hormones affect extended amygdala to medial prefrontal cortex (mPFC) circuit functioning, but it is unclear whether they relate to white matter microstructure connecting these regions. We examined this question in 139 trauma-exposed adults (81 female; ages 19-54) who completed the Clinician-Administered PTSD Scale, a blood draw, and diffusion magnetic resonance imaging. White matter integrity was assessed in tracts connecting the extended amygdala to mPFC, including the uncinate fasciculus, frontal parahippocampal cingulum, and bed nucleus of the stria terminalis to mPFC projections. We used both tract-average fractional anisotropy (FA) to assess the global integrity of these white matter tracts and restricted connectometry to identify spatially localized associations along specific tract segments. Neither cortisol nor PACAP levels were associated with tract-average FA in any tract. However, connectometry, using a stringent statistical T-threshold revealed distinct, region-specific associations within the dorsal cingulum: higher cortisol levels were associated with lower FA (

Indexed as

cingulumcortisoldiffusion magnetic resonance imagingpituitary adenylate cyclase-activating peptideposttraumatic stress disorder

Identifiers

PMID40502553
PMCPMC12155003

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.