Evidence map›Paper›PMID 40502510›Full record

ArticleWorld journal of gastrointestinal surgery2025

Methyltransferase-like factor 14 pathway and its relationship with pathological stages in patients undergoing surgery for colorectal cancer.

Qun Dai, Peng-Fei Ma, Jing Tian, Zhan Zhang, Qin Fang, Zi-Yu Lin, Li-Li Wu, Xue-Min Li

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Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Qun DaiDepartment of Pathology, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University, Hefei 230022, Anhui Province, China.
Peng-Fei MaDepartment of Gastroenterology, Children's Hospital of Fudan University at Anhui, Anhui Provincial Children's Hospital, Hefei 230022, Anhui Province, China.
Jing TianDepartment of Pathology, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University, Hefei 230022, Anhui Province, China. 305820252@qq.com.
Zhan ZhangDepartment of Pathology, South District, The First Affiliated Hospital of Anhui Medical University, Feixi 231200, Anhui Province, China.
Qin FangDepartment of Pathology, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University, Hefei 230022, Anhui Province, China.
Zi-Yu LinDepartment of Pathology, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University, Hefei 230022, Anhui Province, China.
Li-Li WuDepartment of Pathology, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University, Hefei 230022, Anhui Province, China.
Xue-Min LiDepartment of Pathology, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University, Hefei 230022, Anhui Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpigenetic involvement of methyltransferase-like factor 14 (METTL14) in tumor development has not been clearly defined.

aimTo investigate METTL14 expression and its relationship with pathological stage in patients undergoing radical surgery for colorectal cancer (CRC).

methodsThis retrospective study included 80 patients with CRC who were admitted to the Third Hospital of Hefei and the Western District of the First Affiliated Hospital of Anhui Medical University between June 2021 and June 2024. These patients were selected for treatment. Lesions and adjacent tissues were collected from these patients, and METTL14 expression was assessed using immunohistochemistry. Expression levels of METTL14 were compared across different tissue samples. Additionally, we evaluated METTL14 expression in patients with varying pathological characteristics using statistical methods such as

resultsThe positivity rate of METTL14 in tumor tissues was significantly lower than that in adjacent tissues (30%

conclusionIn CRC, low positive METTL14 expression is closely correlated with lymph node metastasis, invasion depth T3 + T4, and TNM stage, indicating the malignant biological behavior of rectal cancer.

Indexed as

Clinical pathologyColorectal cancerMethyltransferase-like factor 14Radical resectionTreatment

Identifiers

PMID40502510
PMCPMC12149940

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