ArticleMaterials today. Bio2025
TGF-β1/BSA coating modulates multi-phasic scaffolds for osteochondral tissue regeneration.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Graphene oxide-modified PEEK composites: Properties and applications in orthopaedic repair - A review.Journal of orthopaedic translation · 2026Review
- The application of tissue engineering in cartilage regeneration: technological advances and future challenges.Frontiers in bioengineering and biotechnology · 2026Review
- Research progress of 3D-printed PLGA scaffolds for the treatment of bone defects.Biomedical engineering online · 2025Review
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Authors and funding
5 authors.
Funding
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Abstract
Bioinspired scaffolds, designed to replicate distinct regions and mimic stratified anatomical architecture, have emerged as a promising approach for addressing osteochondral defects (a joint injury affecting both cartilage and underlying bone). Despite extensive preclinical research, the challenge of integrating newly formed bone and cartilage has hindered clinical adoption, driving the continuous development of more effective constructs. To address this issue, we propose an approach centred on a protein-modified stratified multi-phasic scaffolds. In this investigation, we developed a bottom layer composed of polydopamine-modified 3D printed poly (lactic-co-glycolic acid) (PLGA) scaffolds loaded with simvastatin, complemented by an upper layer consisting of electrospun PLGA-gelatine fibres obtained by a green strategy, e.g., using a benign solvent. Scaffolds were then coated with transforming growth factor-β1 (TGF-β1)- bovine serum albumin (BSA). The multi-phasic scaffolds exhibited a hierarchical interconnected porous microstructure with hydrophilicity characterized by a contact angle of 24° and a swelling rate of 467 % over 24 h (n = 5), contributing to
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