Evidence map›Paper›PMID 40502331›Full record

ArticleInternational journal of general medicine2025

An Assessment of Endothelial Markers in Patients with Uncomplicated Malaria in Jazan Province, Saudi Arabia.

Aymen Madkhali, Gasim Dobie, Abdullah A Mobarki, Khaled Essawi, Waleed Hakami, Abdulrahim R Hakami, Mohammed H Nahari, Yahya H Matari, Raneem Alhazmi, Mohammed Alkurbi and 7 more

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Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aymen MadkhaliDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Gasim DobieDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.ORCID 0000-0002-9225-1709
Abdullah A MobarkiDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Khaled EssawiDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.ORCID 0009-0003-9556-5249
Waleed HakamiDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Abdulrahim R HakamiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Mohammed H NahariDepartment of Medical Laboratory Technology, Najran University, Najran, Saudi Arabia.ORCID 0000-0002-3499-4678
Yahya H MatariDepartment of Hematology and Blood Bank, Baish General Hospital, Jazan, Saudi Arabia.
Raneem AlhazmiRiyadh Medical Clinic Complex, Riyadh, Saudi Arabia.
Mohammed AlkurbiDepartment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Shaqraa MusawiDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.ORCID 0000-0002-7959-4010
Yara AlyahyawiDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Fatemah A AlhakamiDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.ORCID 0009-0008-3521-6043
Mohammad S AkhterDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.ORCID 0000-0003-0426-5551
Muhammad SaboorDepartment of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.ORCID 0000-0002-2901-0216
Ali HakamyNursing Department, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Hassan A HamaliDepartment of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.ORCID 0000-0003-3791-460X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malaria continues to be a life-threatening disease that affects people in tropical and sub-tropical regions. Endothelial cells play a key role in the pathogenicity and severity of malaria. This study aimed to assess circulating endothelial cell markers and their correlation with routine laboratory parameters and parasite density in malaria patients compared to matched healthy controls. Materials and Methods: This study included 34 patients with non-severe Results: The findings revealed significantly elevated levels of E-selectin, ICAM-1, and VCAM-1 in malaria patients compared to controls. In addition, multivariable analysis indicated that age, hemoglobin levels, platelet counts, prothrombin time, and E-selectin levels were significantly associated with malaria infection, but no association was found between circulating endothelial markers and parasite density. Conclusion: The data suggest a significant role for E-selectin, ICAM-1, and VCAM-1 in the pathogenesis of malaria infection and their potential use alongside laboratory parameters as indicators of endothelial dysfunction in malaria.

Indexed as

endothelial cell markersE-selectinICAM-1laboratory parametersmalariaVCAM-1

Identifiers

PMID40502331
PMCPMC12154527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.