ArticleJournal of biomedical optics2025
Multimodal optical coherence tomography and two-photon light sheet fluorescence microscopy for embryo imaging.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Multimodal optical imaging for the assessment of the teratogenic effects of ethanol on zebrafish development.Journal of biomedical optics · 2026Article
- Imaging-based tracking of stem-cell responses for 3D bioprinting optimization.Cell transplantationReview
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Authors and funding
9 authors.
Funding
Abstract
Significance: Structural and molecular imaging of the developing embryo can provide deep insights into the development of various pathologies, but few techniques enable the simultaneous detection of these parameters. We demonstrate the first use of combined optical coherence tomography and two-photon light sheet fluorescence microscopy (2P-LSFM) for simultaneous structural and molecular imaging. Aim: We aim to develop a multimodal high-resolution embryonic system that facilitates simultaneous structural and molecular embryonic imaging. Approach: We have developed a multimodal imaging system in which the optical coherence tomography (OCT) and light sheet illumination beams were optically co-aligned and scanned through the galvanometer-mounted mirrors and the same illumination objective. Results: The swept-source OCT system provides a lateral resolution of Conclusions: The co-alignment of the OCT and 2P-LSFM systems enables simple image registration and high-throughput multimodal imaging.
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Registered trials
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