Evidence map›Paper›PMID 40502296›Full record

ArticleOphthalmology science

Regional Variation in Guttae Distribution in Fuchs Endothelial Corneal Dystrophy.

Yasufumi Tomioka, Morio Ueno, Akihisa Yamamoto, Koji Kitazawa, Hideki Fukuoka, Motomu Tanaka, Chie Sotozono, Ula V Jurkunas, Shigeru Kinoshita

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In one paragraph

Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Yasufumi TomiokaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Morio UenoDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Akihisa YamamotoDepartment of Mechanical Systems Engineering, Graduate School of Systems Design, Tokyo Metropolitan University, Tokyo, Japan.
Koji KitazawaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hideki FukuokaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Motomu TanakaInstitute for Physical Chemistry, Heidelberg University, Heidelberg, Germany.
Chie SotozonoDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ula V JurkunasCornea Center of Excellence, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts.
Shigeru KinoshitaDepartment of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate regional variations in guttae distribution in Fuchs endothelial corneal dystrophy (FECD) and evaluate its relationship with anatomical ultraviolet (UV) protection by the eyelid. Design: A prospective observational study. Participants: This study involved 19 eyes of 19 patients with FECD between April 2022 and June 2024 at Kyoto Prefectural University of Medicine. Methods: Using slit-scanning wide-field contact specular microscopy, we analyzed guttae distribution in 5 corneal regions (central, superior, temporal, nasal, and inferior). Marginal reflex distance (MRD) was measured to assess the eyelid position. Proportion of guttae was quantified using image analysis. Main Outcome Measures: Regional differences in guttae distribution and correlation with MRD measurements. Results: The superior region demonstrated a significantly lower proportion of guttae (29.4%) compared with central (69.0%), temporal (57.4%), and nasal areas (57.5%) (all Conclusions: Our study reveals a distinct regional variation in FECD progression, with relative sparing of the superior cornea suggesting potential UV-protective mechanisms. Although not directly correlated with eyelid position, these findings indicate that environmental factors may influence disease progression. This insight suggests the potential benefit of UV protection as a preventive strategy, particularly in early-stage FECD patients. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Corneal endothelial cellsFuchs endothelial corneal dystrophyGuttaeSlit-scanning wide-field contact specular microscopyUltraviolet protection

Identifiers

PMID40502296
PMCPMC12156161

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.