ArticleOphthalmology science
Quantification of Hyperreflective Foci in Age-related Macular Degeneration by Polarization-Sensitive OCT.
Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Faricimab for treatment-naïve nAMD: 1- and 2-year outcomes and PS-OCT polarimetric entropy.International ophthalmology · 2026Article
- Polarimetric entropy mapping of retinal pigment epithelium in full-thickness macular hole by polarization-sensitive OCT.BMC ophthalmology · 2026Article
- Polarization-Sensitive OCT Assessment of Retinal Emboli in Branch Retinal Artery Occlusion: A Pilot Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Evaluation of Leak Sites in Central Serous Chorioretinopathy and the Effects of PDT on RPE by Polarization-Sensitive OCT.Translational vision science & technology · 2025Article
- Evaluation of Reticular Pseudodrusen by Polarization-Sensitive Optical Coherence Tomography: Case Report.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To quantify hyperreflective foci (HRF) using polarization-sensitive OCT (PS-OCT) and evaluate the effect of anti-VEGF therapy on HRF reduction. Design: Retrospective study. Subjects: Twelve eyes from 12 patients with neovascular age-related macular degeneration (nAMD) who underwent PS-OCT imaging before and after 4 intravitreal injections of faricimab, administered every 4 weeks. Methods: Retinal layers between the inner border of the inner nuclear layer and the outer border of the outer segment of photoreceptors were analyzed. Regions with entropy values exceeding the mean + 2 standard deviations from healthy controls (entropy: 0.0896 ± 0.0270) were isolated to quantify hyperentropic foci (HEF), representing HRF. Main Outcome Measures: The sum and area of HEF were calculated as total HEF and area aggregate to compare before and after the treatment. Results: The mean patient age was 77.4 ± 8.6 years, with an equal distribution of males and females (6 each). Total HEF was significantly associated with worse baseline visual acuity (coefficient: 0.0015297, Conclusions: Polarization-sensitive OCT is a valuable imaging modality for extracting and quantifying HRF in the neurosensory retina. Faricimab significantly reduces HEF in nAMD eyes, highlighting its potential therapeutic effect beyond conventional OCT-detected changes. Financial Disclosures: Proprietary or commercial disclosures may be found in the Footnotes and Disclosures at the end of this article.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.