Evidence map›Paper›PMID 40502240›Full record

ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2025

An Implemented Real-World-Data Pipeline for Standardization of Electronic Health Records in Precision Oncology.

Kory Kreimeyer, Durrant Barasa, Mohamed Sherief, Xiaorui Shi, Marvin Borja, Srinivasan Yegnasubramanian, Valsamo Anagnostou, Joseph C Murray, Taxiarchis Botsis

Abstract read
In one paragraph

Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kory KreimeyerSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Durrant BarasaSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Mohamed SheriefSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Xiaorui ShiBiomedical Informatics and Data Science Section, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD.
Marvin BorjaThe Johns Hopkins Surgery Center for Outcomes Research, Johns Hopkins University School of Medicine, Baltimore, MD.
Srinivasan YegnasubramanianSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Valsamo AnagnostouSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Joseph C MurraySidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.
Taxiarchis BotsisSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD.

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
Matching genotypes with personalized therapies: Development of a decision support infrastructure to augment the value of precision medicineU01CA274631 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANAGNOSTOU, VALSAMO, BOTSIS, TAXIARCHIS · 2023 to 2025
$1.2M
NCI NIH HHS P30 CA006973NCI NIH HHS U01 CA274631
6 · The paper itself

Abstract

Several use cases in precision oncology require accurately extracting and standardizing Real-World Data from Electronic Health Records (EHRs). We developed the infrastructure and a toolset incorporating data mining and natural language processing scripts to automatically retrieve selected descriptive and common endpoint variables from EHRs. This toolset was evaluated against a reference dataset of 106 lung cancer and 45 sarcoma patient cases pulled from two databases complying with the Precision Oncology Core Data Model (Precision-DM) and maintained by the Johns Hopkins Molecular Tumor Board and a research team. We accurately retrieved most descriptive EHR fields but less efficiently extracted the Date of Diagnosis and Treatment Start Date that supported calculating the Age at Diagnosis, Overall Survival, and Time to First Treatment (accuracy range 50%-86%). Our infrastructure and Precision-DM-based standardization could inspire similar efforts in other cancer centers, however, the toolset should be enhanced to improve accuracy in certain variables.

Identifiers

PMID40502240
PMCPMC12150718

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.