Evidence map›Paper›PMID 40502204›Full record

ArticlebioRxiv : the preprint server for biology2025

Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Defects through Dysregulation of DNA Methylation.

Bernard K van der Veer, Colin Custers, Wannes Brangers, Riet Cornelis, Spyridon Champeris Tsaniras, Kobe De Ridder, Bernard Thienpont, Huiyong Cheng, Qiuying Chen, Daniel Kraushaar and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bernard K van der VeerLaboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.ORCID 0000-0002-2576-7529
Colin CustersLaboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.
Wannes BrangersLaboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.
Riet CornelisLaboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.
Spyridon Champeris TsanirasLaboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.
Kobe De RidderLaboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium.
Bernard ThienpontLaboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium.ORCID 0000-0002-8772-6845
Huiyong ChengDepartment of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.
Qiuying ChenDepartment of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.ORCID 0000-0001-5909-3959
Daniel KraushaarDepartment of Molecular and Cellular Biology, Genomic and RNA Profiling Core, Baylor College of Medicine, Houston, Texas, USA.
Richard H FinnellDepartment of Molecular and Cellular Biology, Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, USA.
Steven S GrossDepartment of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.
Kian Peng KohLaboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.

Funding

Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7M
HIGH THROUGHPUT NGS SEQUENCER AT THE BCM GENOMIC AND RNA PROFILING CORES10OD036427 · OD · BAYLOR COLLEGE OF MEDICINE · PI KRAUSHAAR, DANIEL · 2024 to 2024
$600k
NIEHS NIH HHS P30 ES030285NIH HHS S10 OD036427
6 · The paper itself

Abstract

Maternal dietary insufficiencies can reshape the fetal epigenome during gestation, contributing to birth defects and developmental disorders. Vitamin C (VitC) is a critical co-factor for Ten-Eleven-Translocation (TET) DNA demethylases, but the impact of its deficiency on embryonic development has gone largely unappreciated. Here, we show that maternal VitC deficiency in L-gulonolactone oxidase (

Identifiers

PMID40502204
PMCPMC12154938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.