Evidence map›Paper›PMID 40502160›Full record

ArticlebioRxiv : the preprint server for biology2025

Temporally-segregated dual functions for Gfi1 in the development of retinal direction-selectivity.

Karina Chaudhari, Luis E Guzman-Clavel, Alex L Kolodkin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Karina ChaudhariSolomon H. Snyder Department of Neuroscience, The Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-3533-3027
Luis E Guzman-ClavelSolomon H. Snyder Department of Neuroscience, The Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-1020-9708
Alex L KolodkinSolomon H. Snyder Department of Neuroscience, The Johns Hopkins Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0001-7562-5513

Funding

Molecular mechanisms underlying direction-selective circuit assembly and function in the mouse visual systemR01EY032095 · NEI · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2021 to 2025
$2.3M
NEI NIH HHS R01 EY032095
6 · The paper itself

Abstract

There is great diversity in retinal ganglion cells subtypes in the mouse retina, but little is known about the molecular factors required to generate this subtype diversity. Here, we identify the transcription factor Gfi1 as a conserved driver of differentiation specifically in two downward-tuned direction selective ganglion cells (DSGCs). Further, we describe a post-differentiation role for Gfi1 in regulating dendritic development of Down ON-type DSGCs crucial for their ability to detect downward motion. These results define novel temporally-segregated dual functions for Gfi1 in the development of retinal direction-selective circuits, and they provide a framework for understanding fundamental mechanisms underlying direction-selectivity in the retina.

Identifiers

PMID40502160
PMCPMC12157548

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.