Evidence map›Paper›PMID 40502131›Full record

ArticlebioRxiv : the preprint server for biology2025

Bidirectional modulation of accumbens dopamine by MCH neurons during learning and consummatory behavior.

Liam E Potter, Brandon A Toth, Jayeeta Manna, Hannah C Lyons, Jack R Evans, Christian R Burgess

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Liam E PotterMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI USA.
Brandon A TothMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI USA.
Jayeeta MannaMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI USA.
Hannah C LyonsMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI USA.
Jack R EvansMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI USA.
Christian R BurgessMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI USA.ORCID 0000-0001-6133-8089

Funding

Elucidating the role for MCH neurons in feeding behavior and responses to sensory food cuesR01DK129366 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURGESS, CHRISTIAN RICHARD · 2021 to 2025
$2.1M
Monoaminergic and limbic systems underlying narcolepsy-cataplexyF31NS132434 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brandon Anthony Toth · 2024 to 2026
$124k
NIDDK NIH HHS R01 DK129366NINDS NIH HHS F31 NS132434
6 · The paper itself

Abstract

The formation of sensory cue-reward associations is essential for survival, but in the modern calorie-rich and advertising-intensive environment, such associations may become maladaptive - leading to negative health consequences such as obesity or diabetes. Recent research has demonstrated the importance of hypothalamic melanin-concentrating hormone (MCH)-expressing neurons in driving hedonically-motivated feeding and in forming these associations. The MCH system interacts with mesolimbic dopamine (DA) transmission, offering a potential mechanism for the effects of MCH neurons on hedonic feeding and associative conditioning. However, this interaction has not been fully characterized

Identifiers

PMID40502131
PMCPMC12157353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.