ArticlebioRxiv : the preprint server for biology2025
Aromatic Patch in WhiB-Like Transcription Factors Facilitates Primary Sigma Factor Interaction in
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
WhiB-like (Wbl) family proteins are a group of small iron-sulfur ([4Fe-4S]) cluster-containing transcription factors and are uniquely found in Actinobacteria and actinobacteriophages. They play pivotal roles in diverse biological processes, including cell development, redox stress response and antibiotic resistance. However, the lack of a canonical DNA binding motif in most Wbl proteins has long obscured the mechanistic understanding of how Wbl family proteins regulate gene expression. Previous studies have shown several members of Wbl family proteins from SIGNIFICANCE: This work addresses a critical knowledge gap in understanding how WhiB-like (Wbl) family proteins regulate gene expression and confer virulence and antibiotic resistance in
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