Evidence map›Paper›PMID 40502111›Full record

ArticlebioRxiv : the preprint server for biology2025

Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension.

E S Villarreal, Y Marinho, O Loya, S Y Aboagye, D L Williams, J Sun, S Erzurum, V de Jesus Perez, S D Oliveira

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

E S Villarreal
Y Marinho
O Loya
S Y Aboagye
D L Williams
J SunORCID 0000-0001-7465-3133
S Erzurum
V de Jesus PerezORCID 0000-0001-5532-8247
S D OliveiraORCID 0000-0002-7654-1909

Funding

Generation of Endothelial Cell Memory in Inflammatory Vascular DiseaseK01HL159037 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOS SANTOS OLIVEIRA, SUELLEN D'ARC · 2021 to 2025
$800k
NHLBI NIH HHS K01 HL159037
6 · The paper itself

Abstract

Schistosomiasis-associated Pulmonary Hypertension (Sch-PH) is the most common form of group I PH worldwide. Recently, data revealed that the preclinical animal model of Sch-PH exhibited gut and lung microbiome dysbiosis linked to significant endothelial dysfunction and microvascular apoptosis, but the role of pro/anti-apoptosis sensors, such as the inhibitor of apoptosis protein 2 (c-IAP2) and purinergic receptor P2X7 (P2X7R), remained unclear. Using a novel Cdh5cre-ER

Identifiers

PMID40502111
PMCPMC12154776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.