Evidence map›Paper›PMID 40502076›Full record

ArticlebioRxiv : the preprint server for biology2025

Quantifying Conformational Heterogeneity of 3D Genome Organization in Fruit Fly.

Samira Mali, Igor S Tolokh, Erik Cross, Alexey V Onufriev

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Samira MaliDepartment of Computer Science, Virginia Polytechnic Institute and State University, Blacksburg VA, USA.
Igor S TolokhDepartment of Computer Science, Virginia Polytechnic Institute and State University, Blacksburg VA, USA.
Erik CrossDepartment of Life Science, Rensselaer Polytechnic Institute, Troy NY, USA.
Alexey V OnufrievDepartment of Computer Science, Virginia Polytechnic Institute and State University, Blacksburg VA, USA.ORCID 0000-0002-4930-6612

Funding

Next generation implicit solvation for atomistic modelingR01GM144596 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI ONUFRIEV, ALEXEY VLAD · 2022 to 2025
$1.2M
NIGMS NIH HHS R01 GM144596
6 · The paper itself

Abstract

The three-dimensional (3D) organization of interphase chromatin in eukaryotes is complex; details of the corresponding genome structures vary stochastically from cell to cell. Here, we propose a metric to quantify the cell-to-cell heterogeneity of the 3D chromatin conformations in ensembles of single cells:

Identifiers

PMID40502076
PMCPMC12154688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.