Evidence map›Paper›PMID 40502073›Full record

ArticlebioRxiv : the preprint server for biology2025

Competing Subclones and Fitness Diversity Shape Tumor Evolution Across Cancer Types.

Hai Chen, Jingmin Shu, Rekha Mudappathi, Elaine Li, Panwen Wang, Leif Bergsagel, Ping Yang, Zhifu Sun, Logan Zhao, Changxin Shi and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Hai ChenCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Jingmin ShuCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Rekha MudappathiCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Elaine LiEmory University, Atlanta, GA 30322, USA.
Panwen WangDepartment of Quantitative Health Sciences, Mayo Clinic, Arizona, Scottsdale, 85259, USA.
Leif BergsagelMayo Clinic, Scottsdale, AZ, USA.
Ping YangDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ 85259, USA.
Zhifu SunDivision of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Logan ZhaoDivision of Hematology/Oncology, Department of Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Changxin ShiDivision of Hematology/Oncology, Department of Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Jeffrey P TownsendDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, 06520.
Carlo MaleyBiodesign Institute, Arizona State University, Tempe, AZ 85281, USA.
Li LiuCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.ORCID 0000-0003-4002-7497

Funding

Molecular, Cellular and Tissue Characterization UnitU2CCA233254 · NCI · DUKE UNIVERSITY · PI HWANG, E.SHELLEY · 2018 to 2023
$11.4M
The Role of the Microbiome in Cancer Suppression and Susceptibility Across SpeciesU54CA217376 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MALEY, CARLO · 2018 to 2022
$8.6M
Modeling Neoplastic Progression in Barrett's Esophagus - Renewal -2R01CA140657 · NCI · WISTAR INSTITUTE · PI Carlo Maley · 2009 to 2026
$5.0M
Discover and Analyze Germline-Somatic Interactions in CancerR01LM013438 · NLM · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LIU, LI, YANG, PING · 2021 to 2023
$1.0M
A cell-cycle induced genetic recorder for simultaneous recovery of cell divisions and lineageR21CA257980 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MALEY, CARLO, WEISS, RON · 2022 to 2023
$576k
NCI NIH HHS R01 CA140657NCI NIH HHS R21 CA257980NCI NIH HHS U2C CA233254NCI NIH HHS U54 CA217376NLM NIH HHS R01 LM013438
6 · The paper itself

Abstract

Intratumor heterogeneity arises from ongoing somatic evolution complicating cancer diagnosis, prognosis, and treatment. Here we present TEATIME (es

Indexed as

Cancer EvolutionCancer GenomicsComputational Biology

Identifiers

PMID40502073
PMCPMC12157508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.