ArticlebioRxiv : the preprint server for biology2025
A fluorescent reporter and single-turnover kinetics reveal new insight into BAM complex function.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The β-barrel assembly machine (BAM) is an essential protein complex that folds and inserts outer membrane β-barrel proteins (OMPs) into the bacterial outer membrane. The BAM complex contains the essential BamA OMP with five soluble polypeptide transport-associated (POTRA) domains, which scaffold the essential BamD lipoprotein and the non-essential lipoproteins BamB/C/E. The importance of each BAM component has been investigated primarily using cell-based phenotypic assays, and structural data have revealed insights into the role of the BamA β-barrel in OMP folding. However, Significance: The folding of outer membrane proteins (OMPs) in Gram-negative bacteria requires the essential β-barrel assembly machine (BAM). By developing a fluorescent OMP folding reporter, we have unlocked insight into BAM activity
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