Evidence map›Paper›PMID 40502009›Full record

ArticlebioRxiv : the preprint server for biology2025

Beneficial and detrimental consequences of AHR activation in intestinal infection.

Oscar E Diaz, Liang Zhou, Christopher Barrington, Dennis Lindqvist, Frederike Graelmann, Emma Wincent, Brigitta Stockinger

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Oscar E DiazThe Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-7622-7832
Liang ZhouUniversity of Florida, College of Veterinary Medicine, Department of Infectious Diseases and Immunology, Gainesville, FL, USA, 32608.
Christopher BarringtonThe Francis Crick Institute, London NW1 1AT, UK.
Dennis LindqvistDepartment of Environmental Science, Stockholm University, Stockholm, Sweden.
Frederike GraelmannImmunology and Environment, Life & Medical Sciences (LIMES) Institute, University of Bonn, Germany.
Emma WincentInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0003-1637-654X
Brigitta StockingerThe Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-8781-336X

Funding

Regulation of Gut Innate Lymphoid Cells by AhrR01AI132391 · NIAID · UNIVERSITY OF FLORIDA · PI Liang Zhou · 2017 to 2026
$4.8M
Role of RORgt+ (note: g: is gamma symbol) lymphocytes in Gut Tissue HomeostasisR01AI157109 · NIAID · UNIVERSITY OF FLORIDA · PI ZHOU, LIANG · 2021 to 2025
$2.8M
NIAID NIH HHS R01 AI132391NIAID NIH HHS R01 AI157109Wellcome Trust 210556/Z/18/ZWellcome Trust FC001159
6 · The paper itself

Abstract

The ligand dependent transcription factor aryl hydrocarbon receptor (AHR) is an environmental sensor whose activation can have physiologically beneficial or detrimental consequences for host immune responses depending on the ligand. Here we investigated the hypothesis that prolonged AHR activation either due to inefficient ligand metabolism or due to genetic manipulation may underlie the distinction between beneficial and detrimental effects. Our data indicate that prolonged AHR activation caused toxic endpoints for liver and thymus but was not per se interfering with the host response to infection with the intestinal pathogen

Indexed as

Aryl hydrocarbon receptorATAC-seqCitrobacter rodentiumintestinescRNAseq

Identifiers

PMID40502009
PMCPMC12154909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.