Evidence map›Paper›PMID 40502002›Full record

ArticlebioRxiv : the preprint server for biology2025

Investigating oncoprotein-mediated chromatin dysregulation in

Samuel D Krabbenhoft, Tyler E Masuda, Yadwinder Kaur, Truman J Do, Siddhant U Jain, Peter W Lewis, Melissa M Harrison

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samuel D KrabbenhoftDepartment of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.
Tyler E MasudaDepartment of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.
Yadwinder KaurDepartment of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.
Truman J DoDepartment of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.
Siddhant U JainDepartment of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.
Peter W LewisDepartment of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-9816-7823
Melissa M HarrisonDepartment of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-8228-6836

Funding

Shared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MAJEWSKI, JACEK · 2015 to 2024
$17.6M
Understanding the regulation of PRC2 activity by EZHIP and the K27M oncohistone in pediatric gliomasR01CA266861 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Peter W Lewis · 2023 to 2026
$1.3M
Determining mechanisms of PRC2-mediated disease using DrosophilaF30CA260987 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KRABBENHOFT, SAMUEL DAVID · 2021 to 2023
$117k
NCI NIH HHS F30 CA260987NCI NIH HHS P01 CA196539NCI NIH HHS R01 CA266861
6 · The paper itself

Abstract

Polycomb Repressive Complex 2 (PRC2) maintains epigenetic repression through the catalysis of H3K27 trimethylation (H3K27me3), which restricts gene expression and preserves developmental gene-regulatory networks. The integrity of PRC2-mediated gene silencing depends critically on the ability of PRC2 to establish and propagate H3K27me3 beyond initial recruitment sites. The oncoproteins EZHIP and histone H3 K27M specifically inhibit this propagation by blocking the allosterically activated state of PRC2, leading to global disruption of H3K27me3 patterns and developmental abnormalities. To uncover chromatin-related pathways intersecting with PRC2 repression, we developed a

Identifiers

PMID40502002
PMCPMC12154851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.