Evidence map›Paper›PMID 40501990›Full record

ArticlebioRxiv : the preprint server for biology2025

Synthetic cargo adaptors reveal molecular features that can enhance dynein activation.

Aravintha Siva, John P Gillies, Ashley de Borchgrave, Sharon R Garrott, Rishi Mishra, Rita El Jbeily, Reagan S Clarke, Cameron Conklin, Daytan Gibson, Juliana L Zang and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Aravintha SivaUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.
John P GilliesUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.
Ashley de BorchgraveUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.
Sharon R GarrottUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.
Rishi MishraUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.
Rita El JbeilyUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.
Reagan S ClarkeUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.
Cameron ConklinUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.
Daytan GibsonUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.
Juliana L ZangUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.
Morgan E DeSantisUniversity of Michigan, Department of Molecular Cellular and Developmental Biology, Ann Arbor, MI 48109.ORCID 0000-0002-4096-8548

Funding

Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
Mechanisms of chromosome motility during mammalian meiosisR01HD108809 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jayakrishnan Nandakumar · 2022 to 2026
$2.4M
Mechanisms of dynein regulationR35GM146739 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Morgan DeSantis · 2022 to 2026
$1.7M
NICHD NIH HHS R01 HD108809NIGMS NIH HHS R35 GM146739NIGMS NIH HHS T32 GM145304
6 · The paper itself

Abstract

Cytoplasmic dynein-1 (dynein) is the primary retrograde-directed microtubule motor in most eukaryotes. To be active, dynein must bind to the dynactin complex and a cargo-specific adaptor to form the

Identifiers

PMID40501990
PMCPMC12157435

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.