ArticlebioRxiv : the preprint server for biology2025
Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimer's disease.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
Background: In mild cognitive impairment and dementia due to Alzheimer's disease (AD), postmortem and Methods: Cognitively unimpaired participants aged 50-65 with a first-degree family history for AD were genetically screened to select three groups: Results: BFCS amyloid burden was highest among Conclusions: We observed nbM (Ch4), but not MTL volume, to be significantly inversely associated with cortical amyloid burden in cognitively unimpaired, Aβ+, middle-aged adults at varying genetic risk for AD. These findings provide further in vivo evidence suggesting that nbM atrophy is an early structural correlate of AD pathogenesis, potentially preceding MTL atrophy.
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