Evidence map›Paper›PMID 40501969›Full record

ArticlebioRxiv : the preprint server for biology2025

Rational design of tertiary coordination sphere of a heme-based sensor for two-orders enhanced oxygen affinity.

Anoop Rama Damodaran, Eaindra Yee, Rahul L Khade, Murphi Williams, Elizabeth A Apiche, R Hunter Wilson, Edward Hoey, Grant Larson, Ke Shi, Hideki Aihara and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anoop Rama DamodaranDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Eaindra YeeDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Rahul L KhadeDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, 1 Castle Point Terrace, Hoboken, NJ 07030, USA.
Murphi WilliamsDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Elizabeth A ApicheDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
R Hunter WilsonDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Edward HoeyDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Grant LarsonDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Ke ShiDepartment of Biochemistry and Molecular Biology, University of Minnesota, Minneapolis, MN 55455, USA.
Hideki AiharaDepartment of Biochemistry and Molecular Biology, University of Minnesota, Minneapolis, MN 55455, USA.
Yong ZhangDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, 1 Castle Point Terrace, Hoboken, NJ 07030, USA.
Ambika Bhagi-DamodaranDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Structural studies of viral replication and invasionR35GM118047 · NIGMS · UNIVERSITY OF MINNESOTA · PI Hideki Aihara · 2016 to 2026
$6.3M
Training the Next Generation of Chemical BiologistsT32GM132029 · NIGMS · UNIVERSITY OF MINNESOTA · PI Erin Elizabeth Carlson, William Charles Krause Pomerantz · 2019 to 2026
$2.7M
Decoding and Rewiring Enzymatic Redox Signal Transduction PathwaysR35GM138277 · NIGMS · UNIVERSITY OF MINNESOTA · PI Ambika Bhagi · 2020 to 2026
$2.6M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Structure, Spectra, and Roles of Metal and Active Site in HNO Heme Protein CompleR15GM085774 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI ZHANG, YONG · 2008 to 2021
$1.4M
NCRR NIH HHS S10 RR029205NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM133893NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R15 GM085774NIGMS NIH HHS R35 GM118047NIGMS NIH HHS R35 GM138277NIGMS NIH HHS T32 GM132029
6 · The paper itself

Abstract

Biological O

Identifiers

PMID40501969
PMCPMC12154584

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.