Evidence map›Paper›PMID 40501963›Full record

ArticlebioRxiv : the preprint server for biology2025

Episymbiotic Saccharibacteria suppresses epithelial immunoactivation through Type IV pili and TLR2 dependent endocytosis.

Deepak Chouhan, Alex S Grossman, Kristopher A Kerns, Kendall S Stocke, Maya Kim, Pu-Ting Dong, Ajay Kumar, Lei Lei, Richard J Lamont, Jeffrey S McLean and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Deepak ChouhanDepartment of Microbiology, ADA Forsyth Institute, Somerville MA, 02143, USA.ORCID 0000-0002-3749-0280
Alex S GrossmanDepartment of Microbiology, ADA Forsyth Institute, Somerville MA, 02143, USA.ORCID 0000-0003-1661-0383
Kristopher A KernsDepartment of Periodontics, University of Washington, Seattle WA, 98195, USA.ORCID 0000-0002-4380-0062
Kendall S StockeDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.ORCID 0000-0002-0822-1188
Maya KimDepartment of Microbiology, ADA Forsyth Institute, Somerville MA, 02143, USA.
Pu-Ting DongDepartment of Microbiology, ADA Forsyth Institute, Somerville MA, 02143, USA.ORCID 0000-0003-2818-2021
Ajay KumarDepartment of Microbiology, ADA Forsyth Institute, Somerville MA, 02143, USA.
Lei LeiDepartment of Microbiology, ADA Forsyth Institute, Somerville MA, 02143, USA.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.
Jeffrey S McLeanDepartment of Periodontics, University of Washington, Seattle WA, 98195, USA.ORCID 0000-0001-9934-5137
Xuesong HeDepartment of Microbiology, ADA Forsyth Institute, Somerville MA, 02143, USA.
Batbileg BorDepartment of Microbiology, ADA Forsyth Institute, Somerville MA, 02143, USA.ORCID 0000-0002-1797-1730

Funding

Domestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6M
Impact of Saccharibacteria and their bacterial hosts in Periodontal and Inflammatory DiseasesR01DE031274 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Batbileg Bor · 2022 to 2026
$2.5M
Spectral Confocal Imaging Instrumentation for Forsyth Advanced Microscopy Core S10OD034405 · OD · ADA FORSYTH INSTITUTE, INC. · PI BORISY, GARY G · 2023 to 2023
$600k
NIDCR NIH HHS R01 DE023810NIDCR NIH HHS R01 DE031274NIH HHS S10 OD034405
6 · The paper itself

Abstract

Saccharibacteria are episymbionts that require host-bacteria to grow. They are positively associated with inflammatory diseases within the human microbiome, yet their mechanisms for interacting with the human host and contributing to diseases remain unknown. This study investigated interactions between a Saccharibacterium (

Indexed as

EndocytosisEpibiontEpithelial barriergingival inflammationInnate immunityPatescibacteriaPeriodontitisSaccharibacteriaToll like receptorType IV pili

Identifiers

PMID40501963
PMCPMC12157433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.