Evidence map›Paper›PMID 40501958›Full record

ArticlebioRxiv : the preprint server for biology2025

Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling.

Tamara C Chan, Mohit Rastogi, Micah X Williams, Samuel Zhang, Sophia M Shi, Steven R Shuken, Teresa Bartling, Katleen Wild, Micaiah Atkins, Oliver Hahn and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Tamara C ChanNeurosciences Interdepartmental Program, Stanford University School of Medicine, CA, USA.ORCID 0000-0002-1630-395X
Mohit RastogiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, CA, USA.
Micah X WilliamsInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, CA, USA.
Samuel ZhangInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, CA, USA.
Sophia M ShiDepartment of Chemistry, Stanford University, CA, USA.
Steven R ShukenDepartment of Cell Biology, Harvard Medical School, MA, USA.
Teresa BartlingDZNE, German Center for Neurodegenerative Diseases, Tuebingen, Germany.
Katleen WildDZNE, German Center for Neurodegenerative Diseases, Tuebingen, Germany.
Micaiah AtkinsDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, CA, USA.
Oliver HahnDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, CA, USA.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, MA, USA.ORCID 0000-0002-4291-413X
Saša JerebThe Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, USA.
S Andrew ShusterNeurosciences Interdepartmental Program, Stanford University School of Medicine, CA, USA.
Yongjin YooInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, CA, USA.
Alan NapoleInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, CA, USA.
Victoria G HernandezNeurosciences Interdepartmental Program, Stanford University School of Medicine, CA, USA.
Liqun LuoDepartment of Biology, Howard Hughes Medical Institute, Stanford University, CA, USA.
Marion S BuckwalterDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, CA, USA.
Beth StevensF.M. Kirby Neurobiology Center, Boston Children's Hospital, MA, USA.ORCID 0000-0003-4226-1201
Benjamin E DevermanThe Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, USA.
Deborah Kronenberg-VersteegDZNE, German Center for Neurodegenerative Diseases, Tuebingen, Germany.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, MA, USA.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, CA, USA.ORCID 0000-0001-5893-0831
Marius WernigInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, CA, USA.

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
ImageXpress Micro (IXM) Confocal High-content Imaging SystemS10OD026899 · OD · STANFORD UNIVERSITY · PI SOLOW-CORDERO, DAVID EDWARD · 2019 to 2019
$541k
Novel AAV Capsids and Gene Regulatory Elements for GeneExpression in MicrogliaR21MH126409 · NIMH · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E · 2021 to 2022
$440k
NIH HHS S10 OD026899NIMH NIH HHS R21 MH126409NIMH NIH HHS T32 MH020016
6 · The paper itself

Abstract

Microglial tiling-the phenomenon of consistent cell-to-cell distances and non-overlapping processes-is regarded as a qualitative indicator of homeostasis, but mechanisms of microglial tiling are unknown. We used cell-surface proximity labeling and mass spectrometry to profile the microglial cell-surface proteome in an

Identifiers

PMID40501958
PMCPMC12157663

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.