Evidence map›Paper›PMID 40501951›Full record

ArticlebioRxiv : the preprint server for biology2025

G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway.

Esther Liu, Matthew Wright, Andrew O Kearney, Tiffany Caza, Johnson Y Yang, Valerie Garcia, Amal O Dadi, Shuta Ishibe, Navdeep S Chandel, Hanrui Zhang and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Esther LiuDivision of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-2875-5184
Matthew WrightDivision of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Andrew O KearneyDivision of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Tiffany CazaArkana Laboratories, Little Rock, AR 72211, USA.
Johnson Y YangDivision of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Valerie GarciaDivision of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Amal O DadiDivision of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Shuta IshibeSection of Nephrology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Navdeep S ChandelDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0001-7208-3886
Hanrui ZhangDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-8655-938X
Edward B ThorpDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jennie LinDivision of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Training Core for Chicago KUH FORWARDTL1DK132769 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Tamara Isakova · 2021 to 2026
$4.0M
Macrophages and attenuation of inflammation resolution in APOL1 nephropathyR01DK131521 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Pinelopi P. Kapitsinou · 2022 to 2026
$2.9M
Professional Development Core for Chicago KUH FORWARDU2CDK129917 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Nicolae Valentin David · 2021 to 2026
$2.9M
Phagocyte Crosstalk in the Balance of Inflammation & Cardiac DiseaseR35HL177401 · NHLBI · NORTHWESTERN UNIVERSITY · PI Edward Benjamin Thorp · 2025 to 2026
$2.1M
Integrated epidemiology of systemic and plaque-specific immunologic features of human atherosclerosisR01HL175893 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Matthew Joel Feinstein, Edward Benjamin Thorp · 2024 to 2026
$2.1M
Uncovering Mechanisms of Risk-Variant APOL1-modulated Inflammatory Signaling in MacrophagesF31DK131884 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, ESTHER · 2024 to 2025
$89k
NCI NIH HHS P30 CA060553NHLBI NIH HHS R01 HL175893NHLBI NIH HHS R35 HL177401NIDDK NIH HHS F31 DK131884NIDDK NIH HHS R01 DK131521NIDDK NIH HHS TL1 DK132769NIDDK NIH HHS U2C DK129917
6 · The paper itself

Abstract

The G1 and G2 variants of the gene encoding Apolipoprotein L1 (

Identifiers

PMID40501951
PMCPMC12157409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.