Evidence map›Paper›PMID 40501922›Full record

ArticlebioRxiv : the preprint server for biology2025

Kinesin-1 Autoinhibition Tunes Cargo Transport by Motor Ensembles.

Brandon M Bensel, Samantha B Previs, Patricia M Fagnant, Kathleen M Trybus, Sam Walcott, David M Warshaw

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Brandon M BenselDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.ORCID 0000-0002-6523-3513
Samantha B PrevisDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.ORCID 0000-0002-5516-1579
Patricia M FagnantDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.ORCID 0000-0003-2852-1724
Kathleen M TrybusDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.ORCID 0000-0002-5583-8500
Sam WalcottDepartment of Mathematical Sciences, and Bioinformatics and Computational Biology, Worcester Polytechnic Institute, Worcester, MA 01609.ORCID 0000-0002-8871-6964
David M WarshawDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.ORCID 0000-0002-0071-8798

Funding

Multidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1M
Molecular Mechanisms of Motility Deduced from in Vitro Reconstituted Microtubule- and Actin-Based Motor ComplexesR35GM136288 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KATHLEEN M TRYBUS · 2020 to 2026
$2.5M
Equipment supplement - Refeyn TwoMP iSCAT microscopeR35GM141743 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI WARSHAW, DAVID M · 2021 to 2025
$2.3M
Optical Tweezers with Scanning Confocal Fluorescence MicroscopyS10OD026884 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI WARSHAW, DAVID M · 2019 to 2019
$681k
Molecular Motor Cargo Transport: Multidisciplinary Training in In Vitro and In Silico Model SystemsF32GM140618 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BENSEL, BRANDON M. · 2021 to 2022
$91k
NHLBI NIH HHS T32 HL076122NIGMS NIH HHS F32 GM140618NIGMS NIH HHS R35 GM136288NIGMS NIH HHS R35 GM141743NIH HHS S10 OD026884
6 · The paper itself

Abstract

Intracellular vesicular transport by kinesin-1 motors through numerous 3-dimensional (3D) microtubule (MT) intersections must be regulated to support proper vesicle delivery. Knowing kinesin-1 can be regulated via autoinhibition, does kinesin-1 exhibit autoinhibition on cargo, and could this regulate vesicular transport through 3D MT intersections

Identifiers

PMID40501922
PMCPMC12157665

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.