Evidence map›Paper›PMID 40501897›Full record

ArticlebioRxiv : the preprint server for biology2025

Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington's disease.

Matthew Baffuto, Kert Mätlik, Isaac Ilyashov, Maria Esterlita Siantoputri, Hasnahana Chetia, Yurie Maeda, Erika Sipos, Paul Darnell, Laura Kus, Thomas S Carroll and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Matthew BaffutoLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.ORCID 0009-0001-6518-3296
Kert MätlikLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.ORCID 0009-0009-8542-6193
Isaac IlyashovLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.
Maria Esterlita SiantoputriLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.
Hasnahana ChetiaLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.
Yurie MaedaLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.
Erika SiposLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.
Paul DarnellLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.
Laura KusLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.
Thomas S CarrollBioinformatics Resource Center, The Rockefeller University, New York, NY, United States of America.
Douglas BarrowsBioinformatics Resource Center, The Rockefeller University, New York, NY, United States of America.
Christina PresslLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.ORCID 0000-0001-6108-2263
Nicholas DidkovskyLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.
Nathaniel HeintzLaboratory of Molecular Biology, The Rockefeller University, New York, NY, United States of America.

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
Research Education ComponentP30AG072931 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 2021 to 2026
$26.5M
Michigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P · 2016 to 2020
$10.1M
NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG072931NIA NIH HHS U19 AG066567
6 · The paper itself

Abstract

Huntington's disease (HD) is characterized by neuronal dysfunction and degeneration that varies markedly by brain region and cell type. We previously showed that CAG repeat expansion in exon 1 of the

Identifiers

PMID40501897
PMCPMC12154940

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.