Evidence map›Paper›PMID 40501861›Full record

ArticlebioRxiv : the preprint server for biology2025

HEB collaborates with TCR signaling to upregulate

Johanna S Selvaratnam, Juliana Dutra Barbosa da Rocha, Vinothkumar Rajan, Helen Wang, Emily C Reddy, Jenny Jiahuan Liu, Miki S Gams, Cornelis Murre, David L Wiest, Cynthia J Guidos and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Johanna S SelvaratnamBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.ORCID 0000-0002-3713-6302
Juliana Dutra Barbosa da RochaBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Vinothkumar RajanBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.ORCID 0000-0003-3323-181X
Helen WangBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Emily C ReddyHospital for Sick Children, Toronto, ON, Canada.
Jenny Jiahuan LiuBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Miki S GamsDepartment of Immunology, University of Toronto, Toronto, ON, Canada.
Cornelis MurreDepartment of Molecular Biology, University of California at San Diego, La Jolla, CA, USA.ORCID 0000-0003-2437-507X
David L WiestBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0002-0792-3188
Cynthia J GuidosDepartment of Immunology, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-7674-2612
Juan Carlos Zúñiga-PflückerBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.ORCID 0000-0003-2538-3178
Michele K AndersonBiological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.ORCID 0000-0002-8820-5910

Funding

The role of TCR, ligand, and signal strength in human γδ T cell developmentP01AI102853 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI CORNELIS MURRE · 2014 to 2026
$26.3M
NIAID NIH HHS P01 AI102853
6 · The paper itself

Abstract

T cells expressing the γδ T cell receptor (TCR) develop in a stepwise process initiating at the αβ/γδ T cell lineage choice followed by maturation and acquisition of effector functions, including the ability to produce interleukin-17 (IL-17) as γδT17 cells. Previous studies linked TCR signal strength and T cell fate choices to the transcriptional regulator HEB (encoded by

Identifiers

PMID40501861
PMCPMC12157620

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.