Evidence map›Paper›PMID 40501860›Full record

ArticlebioRxiv : the preprint server for biology2025

Spatially organized inflammatory myeloid-CD8

Maximilian Haist, Magdalena Matusiak, Yuqi Tan, Stefanie Zimmer, Henner Stege, Tim Noah Kempchen, Silke Mitschke, Pauline Chu, Beate Weidenthaler-Barth, Graham L Barlow and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Maximilian HaistDepartment of Microbiology and Immunology, Stanford University School of Medicine, 94305, CA, USA.ORCID 0000-0002-6720-7570
Magdalena MatusiakDepartment of Pathology, Stanford University School of Medicine, 94305, CA, USA.ORCID 0000-0002-8201-1621
Yuqi TanDepartment of Microbiology and Immunology, Stanford University School of Medicine, 94305, CA, USA.ORCID 0000-0002-7200-3222
Stefanie ZimmerInstitute of Pathology, University Medical Center Mainz, 55131, Germany.
Henner StegeDepartment of Dermatology, University Medical Center Mainz, 55131, Germany.
Tim Noah KempchenDepartment of Microbiology and Immunology, Stanford University School of Medicine, 94305, CA, USA.
Silke MitschkeMolecular Biosciences/Cancer Biology Program, Heidelberg University, Heidelberg, 48232, Germany.
Pauline ChuDepartment of Pathology, Stanford University School of Medicine, 94305, CA, USA.
Beate Weidenthaler-BarthDepartment of Dermatology, University Medical Center Mainz, 55131, Germany.
Graham L BarlowDepartment of Cancer Immunology and Virology, Dana Farber Cancer Institute, Boston, 02215, MA, USA.
Friederike RogallDepartment of Dermatology, University Medical Center Mainz, 55131, Germany.
Antonio Delgado GonzalezDepartment of Microbiology and Immunology, Stanford University School of Medicine, 94305, CA, USA.
Marc-A BaertschDepartment of Microbiology and Immunology, Stanford University School of Medicine, 94305, CA, USA.
Silvia AlbertiniInstitute of Molecular Virology and Tumor Virology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marisa GariglioVirology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
Cinzia BorgognaVirology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
Yury GoltsevDepartment of Microbiology and Immunology, Stanford University School of Medicine, 94305, CA, USA.
Stephan GrabbeDepartment of Dermatology, University Medical Center Mainz, 55131, Germany.
John W HickeyDepartment of Microbiology and Immunology, Stanford University School of Medicine, 94305, CA, USA.ORCID 0000-0001-9961-7673
Garry P NolanDepartment of Pathology, Stanford University School of Medicine, 94305, CA, USA.

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NOLAN, GARRY P · 2012 to 2021
$49.1M
The Cellular Response to Elafin in PAHP01HL108797 · NHLBI · STANFORD UNIVERSITY · PI ZAMANIAN, ROHAM · 2011 to 2021
$19.7M
Technology CoreU19AI135976 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI ADEREM, ALAN A · 2018 to 2022
$17.0M
The Cellular Geography of Therapeutic Resistance in CancerU2CCA233195 · NCI · DANA-FARBER CANCER INST · PI JOHNSON, BRUCE E. · 2018 to 2023
$13.7M
Spatial-Genomic Integrative Multi-Species Analysis of Lymph Node MetastasisU54CA209971 · NCI · STANFORD UNIVERSITY · PI NOLAN, GARRY P, PLEVRITIS, SYLVIA KATINA · 2016 to 2021
$11.0M
Project 3: Identifying plasma biomarkers predicting time to HIV rebound after treatment interruptionP01AI131374 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI ROAN, NADIA R · 2017 to 2021
$8.5M
Stanford Tissue Mapping Center - STELLARU54HG012723 · NHGRI · STANFORD UNIVERSITY · PI NOLAN, GARRY P, SNYDER, MICHAEL P. · 2022 to 2025
$7.8M
The Lung PCA: A Multi-Dimensional Atlas of Pulmonary PremalignancyU2CCA233238 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DUBINETT, STEVEN M., SPIRA, AVRUM E · 2018 to 2021
$7.0M
Stanford Tissue Mapping CenterU54HG010426 · NHGRI · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2021
$5.1M
Tissue Cytokine Sequestration and Immune Regulation in AutoimmunityU01AI101984 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2021
$5.0M
Studying macrophage polarization in search for predictive and prognostic markers of breast cancerR01CA229529 · NCI · STANFORD UNIVERSITY · PI Robert michael Angelo, Magdalena Matusiak · 2018 to 2026
$3.9M
NCI NIH HHS R01 CA229529NCI NIH HHS U2C CA233195NCI NIH HHS U2C CA233238NCI NIH HHS U54 CA209971NHGRI NIH HHS U54 HG010426NHGRI NIH HHS U54 HG012723NHLBI NIH HHS P01 HL108797NIAID NIH HHS P01 AI131374NIAID NIH HHS U01 AI101984NIAID NIH HHS U01 AI140498NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI100627NIAID NIH HHS U19 AI135976NIDDK NIH HHS UH3 DK114937
6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is an aggressive skin cancer with high propensity for metastasis, caused by Merkel-cell-polyomavirus (MCPyV), or chronic UV-light-exposure. How MCPyV spatially modulates immune responses within the tumor microenvironment and how such are linked to patient outcomes remains unknown. We interrogated the cellular and transcriptional landscapes of 60 MCC-patients using a combination of multiplex proteomics,

Indexed as

head and neck carcinomaImmune-checkpoint blockadeMerkel cell carcinomaMetastasisMultiplexed imagingspatial biologyspatial contextSystems ImmunologyTumor microenvironmentTumor virus

Identifiers

PMID40501860
PMCPMC12157451

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.