Evidence map›Paper›PMID 40501851›Full record

ArticlebioRxiv : the preprint server for biology2025

Correlating membrane-protein dynamics with function: Integrating bioinformatics, molecular dynamics, and single-molecule FRET.

Hugh R Higinbotham, Christine A Arbour, Barbara Imperiali

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Hugh R HiginbothamDepartment of Biology and Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-9418-7958
Christine A ArbourDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-6056-296X
Barbara ImperialiDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-5749-7869

Funding

Structure and function of the monotopic phosphoglycosyl transferase superfamily: Initiators of biosynthesis of complex bacterial glycoconjugatesR01GM131627 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ALLEN, KAREN N. · 2019 to 2025
$3.1M
Design and synthesis of nucleoside-based small molecules to inhibit phosphoglycosyl transferasesF32GM136023 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ARBOUR, CHRISTINE · 2020 to 2023
$234k
NIGMS NIH HHS F32 GM136023NIGMS NIH HHS R01 GM131627
6 · The paper itself

Abstract

We present a strategy that deploys structural bioinformatics, molecular simulation, and single-molecule FRET microscopy for observing the ligand-dependent conformational dynamics of integral membrane proteins

Indexed as

glycoconjugate biosynthesismembrane proteinmolecular dynamicsnon-canonical amino acid mutagenesissingle-molecule FRETsubstrate specificity

Identifiers

PMID40501851
PMCPMC12157426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.