Evidence map›Paper›PMID 40501818›Full record

ArticlebioRxiv : the preprint server for biology2025

Transcription factors SP5 and SP8 drive primary cilia formation.

Yinwen Liang, Richard Koche, Ravindra B Chalamalasetty, Daniel N Stephen, Mark W Kennedy, Zhimin Lao, Yunong Pang, Ying-Yi Kuo, Moonsup Lee, Francisco Pereira Lobo and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Yinwen LiangDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9945-3768
Richard KocheCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6820-5083
Ravindra B ChalamalasettyCancer and Developmental Biology Laboratory, Center for Cancer Research, NCI-Frederick, NIH, Frederick, MD, USA.ORCID 0000-0001-9607-8838
Daniel N StephenDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mark W KennedyCancer and Developmental Biology Laboratory, Center for Cancer Research, NCI-Frederick, NIH, Frederick, MD, USA.
Zhimin LaoDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yunong PangIndependent researcher, New York, USA.ORCID 0000-0002-9207-0502
Ying-Yi KuoDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6876-8126
Moonsup LeeCancer and Developmental Biology Laboratory, Center for Cancer Research, NCI-Frederick, NIH, Frederick, MD, USA.
Francisco Pereira LoboCancer and Developmental Biology Laboratory, Center for Cancer Research, NCI-Frederick, NIH, Frederick, MD, USA.
Xiaofeng HuangDivision of Regenerative Medicine and Hartman Institute for Therapeutic Organ Regeneration, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-8571-4667
Hadjantonakis Anna-KaterinaDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-7580-5124
Terry P YamaguchiCancer and Developmental Biology Laboratory, Center for Cancer Research, NCI-Frederick, NIH, Frederick, MD, USA.ORCID 0000-0002-7452-4419
Kathryn V AndersonDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alexandra L JoynerDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-7090-9605

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
The Role of Wnt Genes in Vertebrate Development and CancerZIABC010345 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YAMAGUCHI, TERENCE · 2009 to 2025
$23.3M
ISOLATION OF NOVEL MUTATIONS AFFECTING THE MOUSE EMBRYOR01HD035455 · NICHD · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI HADJANTONAKIS, ANNA-KATERINA, HUANGFU, DANWEI · 1998 to 2022
$7.1M
The gut endoderm: origin, formation and fateR01DK127821 · NIDDK · SLOAN-KETTERING INST CAN RESEARCH · PI ANNA-KATERINA HADJANTONAKIS · 2021 to 2026
$3.4M
Dynamics of Primary Cilia Formation During Mammalian DevelopmentR01GM126124 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L., TSOU, MENG-FU BRYAN · 2018 to 2021
$2.2M
Intramural NIH HHS ZIA BC010345NCI NIH HHS P30 CA008748NICHD NIH HHS R01 HD035455NIDDK NIH HHS R01 DK127821NIGMS NIH HHS R01 GM126124
6 · The paper itself

Abstract

While specific transcription factors are known to regulate cell fate decisions, the degree to which they can stimulate formation of specific cell organelles is less clear. We used a multi-omics comparison of the transcriptomes of ciliated and non-ciliated embryonic cells to identify transcription factors upregulated in ciliated cells, and conditional genetics in mouse embryos and stem cells to demonstrate that SP5/8 regulate cilia formation and gene expression. In

Identifiers

PMID40501818
PMCPMC12157413

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.