Evidence map›Paper›PMID 40501813›Full record

ArticlebioRxiv : the preprint server for biology2025

Tolerance to Lung Infection in TWIK2 K

Josh Thompson, Yufan Li, Yuanling Song, Ki-Wook Kim, Asrar B Malik, Jingsong Xu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trained immunity in lung injury and repair.Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Josh ThompsonDepartment of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, USA.
Yufan LiShanghai Key Laboratory of Lung Inflammation and Injury, Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yuanling SongShanghai Key Laboratory of Lung Inflammation and Injury, Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Ki-Wook KimDepartment of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, USA.ORCID 0000-0002-7207-4389
Asrar B MalikDepartment of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, USA.
Jingsong XuDepartment of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, USA.ORCID 0000-0001-8261-9509

Funding

TRAINING PROGRAM IN LUNG BIOLOGY AND PATHOBIOLOGYT32HL007829 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 1995 to 2026
$15.6M
Synthetic Biology and Optogenetics CoreP01HL151327 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MEHTA, DOLLY · 2021 to 2025
$11.8M
Role of membrane-associated macrophages in health and inflammationR01DK126753 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KIM, KIWOOK · 2021 to 2025
$2.1M
NHLBI NIH HHS P01 HL151327NHLBI NIH HHS T32 HL007829NIDDK NIH HHS R01 DK126753
6 · The paper itself

Abstract

Alveolar macrophages (AMφ) are essential for innate immune function in the lungs. It is now apparent that macrophages can be trained to become better at attacking infections. Although trained immunity is thought to result from metabolic and epigenetic reprogramming, the underlying mechanisms remain unclear. Here, we report that AMφ can be trained by extracellular ATP, which is ubiquitously released during inflammation. ATP ligates the canonical Purinergic Receptor 2 subtype X7 receptor (P2X7) to mediate endosomal Two-pore domain Weak Inwardly rectifying K

Identifiers

PMID40501813
PMCPMC12154881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.