Evidence map›Paper›PMID 40501783›Full record

ArticlebioRxiv : the preprint server for biology2025

Jeremy E Sandler, Ya-Yin Tsai, Shiyuan Chen, Logan Sabin, Mark E Lush, Abhinav Sur, Elizabeth Ellis, Nhung Tt Tran, Malcolm Cook, Allison R Scott and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jeremy E SandlerStowers Institute for Medical Research, Kansas City, Missouri, USA.
Ya-Yin TsaiStowers Institute for Medical Research, Kansas City, Missouri, USA.
Shiyuan ChenStowers Institute for Medical Research, Kansas City, Missouri, USA.
Logan SabinStowers Institute for Medical Research, Kansas City, Missouri, USA.
Mark E LushStowers Institute for Medical Research, Kansas City, Missouri, USA.
Abhinav SurEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Elizabeth EllisStowers Institute for Medical Research, Kansas City, Missouri, USA.
Nhung Tt TranStowers Institute for Medical Research, Kansas City, Missouri, USA.
Malcolm CookStowers Institute for Medical Research, Kansas City, Missouri, USA.
Allison R ScottStowers Institute for Medical Research, Kansas City, Missouri, USA.
Jonathan S KnissStowers Institute for Medical Research, Kansas City, Missouri, USA.
Jeffrey A FarrellEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.ORCID 0000-0003-4774-1562
Tatjana PiotrowskiStowers Institute for Medical Research, Kansas City, Missouri, USA.

Funding

Zebrafish Sensory Hair Cell RegenerationR01DC015488 · NIDCD · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI Tatjana Piotrowski · 2017 to 2026
$2.9M
A genetic program for organ regeneration in ZebrafishF32DC019023 · NIDCD · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI SANDLER, JEREMY · 2020 to 2022
$213k
NIDCD NIH HHS F32 DC019023NIDCD NIH HHS R01 DC015488
6 · The paper itself

Abstract

Vertebrate mechanosensory hair cells (HCs) in the ear detect sound and gravitational forces. Additionally, fish have homologous lateral line HCs in the skin that detect water vibrations for orientation and predator avoidance. HCs in fish and other non-mammalian vertebrates regenerate to restore function after damage, but mammalian HCs lack this ability, causing deafness and vestibular defects. Experimental attempts at regeneration in mice result in incomplete differentiation of immature HCs. Despite differences in regeneration, the gene regulatory networks (GRNs) driving HC maturation are highly similar across vertebrates. Here, we show that the transcription factor

Indexed as

Cell fategene regulatory networkshair cell evolutionsensory hair cellstranscription factors

Identifiers

PMID40501783
PMCPMC12157520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.