ArticlebioRxiv : the preprint server for biology2025
Genomic and Phenotypic Characterization of Mupirocin Resistant
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Colonization with Methods: We characterized oxacillin and mupirocin susceptibility amongst 384 Results: Mupirocin resistance (MupR) was nearly exclusively present in MRSA strains (103/106 97.1% of MupR; 103/299 34.4% of MRSA). Although our hospital protocol for decolonization shifted to povidone iodine in the Post-COVID period, the overall prevalence of MupR did not change in Pre-COVID and Post-COVID samples (28.9% vs 26%). Genotype correlated with antibiotic susceptibility with low level MupR (MupLR), linked to mutations in Conclusions: Mupirocin resistance was prevalent in our hospital MRSA strains. We also found evidence for emergence and persistence of ST3390 MRSA-MupR strains in Florida. Key points: In a survey of clinical isolates in Florida, 34.4% of MRSA strains were mupirocin resistant. Mupirocin resistance correlated with mutations in
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