Evidence map›Paper›PMID 40501768›Full record

ArticlebioRxiv : the preprint server for biology2025

Tac1 Deficiency Reduces the Severity of Enteric Bacterial Infection.

Elliot Lloyd, Micheal Cremin, Kristina Sanchez, Jungjae Park, Melanie Gareau, Colin Reardon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Elliot LloydDepartment of Anatomy, Physiology & Cell Biology. School of Veterinary Medicine, University of California Davis, Davis, CA.
Micheal CreminDepartment of Anatomy, Physiology & Cell Biology. School of Veterinary Medicine, University of California Davis, Davis, CA.
Kristina SanchezDepartment of Anatomy, Physiology & Cell Biology. School of Veterinary Medicine, University of California Davis, Davis, CA.
Jungjae ParkDepartment of Anatomy, Physiology & Cell Biology. School of Veterinary Medicine, University of California Davis, Davis, CA.
Melanie GareauDepartment of Anatomy, Physiology & Cell Biology. School of Veterinary Medicine, University of California Davis, Davis, CA.
Colin ReardonDepartment of Anatomy, Physiology & Cell Biology. School of Veterinary Medicine, University of California Davis, Davis, CA.

Funding

Animal Models of Infectious Diseases Training ProgramT32AI060555 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI MCSORLEY, STEPHEN J · 2004 to 2025
$3.3M
Initiative for Maximizing Student Development at the University of California, Davis.T32GM135741 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ALDRIN V. GOMES, Manuel F Navedo · 2020 to 2026
$3.2M
Coordination of mucosal immune response to enteric bacterial pathogens by nociceptive innervationR01AI150647 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI REARDON, COLIN · 2020 to 2024
$2.4M
The UC Davis enhanced Molecular, Cellular, and Developmental Biology Training ProgramT32GM153586 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Frederic Louis Chedin, ELVA D DIAZ · 2024 to 2026
$2.3M
NIAID NIH HHS R01 AI150647NIAID NIH HHS T32 AI060555NIGMS NIH HHS T32 GM135741NIGMS NIH HHS T32 GM153586
6 · The paper itself

Abstract

Background: Infection with enteric bacterial pathogens continues to cause significant morbidity and mortality throughout the world. These pathogens include enterohemorrhagic and enteropathogenic Methods: We assessed the role of sensory neurotransmitters encoded by the Results: Conclusions: Sensory neuropeptides regulate key aspects of enteric bacterial infection and may serve as unique targets in the treatment of enteric disease.

Indexed as

inflammationIntestinal inflammationneuroimmuneneuroimmunology

Identifiers

PMID40501768
PMCPMC12154658

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.