Evidence map›Paper›PMID 40501762›Full record

ArticlebioRxiv : the preprint server for biology2025

Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline.

Rui Feng, Sarah F Rosen, Irshad Ansari, Sebastian John, Michael B Thomsen, Oshri Avraham, Cedric G Geoffroy, Valeria Cavalli

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Rui FengDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sarah F RosenDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Irshad AnsariDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sebastian JohnDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael B ThomsenCS27 Bioinformatics, Springboro, OH, USA.
Oshri AvrahamDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cedric G GeoffroyDepartment of Neuroscience & Experimental Therapeutics, Texas A&M Health Science Center, Bryan, TX, 77807, USA.ORCID 0000-0002-7671-147X
Valeria CavalliDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9978-050X

Funding

Multicellular Mechanisms Driving Axon RegenerationR35NS122260 · NINDS · WASHINGTON UNIVERSITY · PI Valeria Cavalli · 2021 to 2026
$4.8M
Functional role of satellite glial cells in axon regenerationR01NS111719 · NINDS · WASHINGTON UNIVERSITY · PI CAVALLI, VALERIA · 2020 to 2021
$885k
Unraveling the transcriptional response of sensory neurons to spinal cord injury at the single cell levelR21NS115492 · NINDS · WASHINGTON UNIVERSITY · PI CAVALLI, VALERIA · 2020 to 2020
$433k
High Sensitivity sCMOS Camera System for Transmission Electron MicroscopeS10OD032186 · OD · WASHINGTON UNIVERSITY · PI PISTON, DAVID W · 2022 to 2022
$147k
NIH HHS S10 OD032186NINDS NIH HHS R01 NS111719NINDS NIH HHS R21 NS115492NINDS NIH HHS R35 NS122260
6 · The paper itself

Abstract

Peripheral sensory neurons regenerate their axons after injury to regain function, but this ability declines with age. The mechanisms behind this decline are not fully understood. While excessive production of endothelin 1 (ET-1), a potent vasoconstrictor, is linked to many diseases that increase with age, the role of ET-1 and its receptors in axon regeneration is unknown. Using single cell RNA sequencing, we show that satellite glial cells (SGCs), which completely envelop the sensory neuron soma residing in the dorsal root ganglia (DRG), express the endothelin B receptor (ETBR), while ET-1 is expressed by endothelial cells. Inhibition of ETBR

Indexed as

AgingAxon regenerationBosentanConnexin 43Dorsal root ganglion (DRG)Endothelin B receptor (ETBR)Nerve injurySatellite glial cells (SGCs)

Identifiers

PMID40501762
PMCPMC12157355

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.