Evidence map›Paper›PMID 40501758›Full record

ArticlebioRxiv : the preprint server for biology2025

Ablation of VEGFA following a lumbar intervertebral disc injury attenuates intradiscal neurovascular features and prevents chronic low back pain symptoms.

Ryan S Potter, Hong J Moon, Sade W Clayton, Remy E Walk, Addison L Liefer, Liufang Jing, Amber N Stratman, Lori A Setton, Munish C Gupta, Simon Y Tang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryan S PotterDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis.ORCID 0009-0007-3740-1288
Hong J MoonDepartment of Orthopaedic Surgery, Washington University School of Medicine.
Sade W ClaytonDepartment of Orthopaedic Surgery, Washington University School of Medicine.ORCID 0000-0002-9798-2594
Remy E WalkDepartment of Biomedical Engineering, Washington University in St. Louis.ORCID 0000-0003-2234-7120
Addison L LieferDepartment of Biomedical Engineering, Washington University in St. Louis.
Liufang JingDepartment of Biomedical Engineering, Washington University in St. Louis.
Amber N StratmanDepartment of Cell Biology and Physiology, Washington University School of Medicine.
Lori A SettonDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis.
Munish C GuptaDepartment of Orthopaedic Surgery, Washington University School of Medicine.
Simon Y TangDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis.ORCID 0000-0002-5570-3921

Funding

Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Intervertebral Disc Degeneration and Cross-Talk with the Nervous System - NOSI Diversity SupplementR01AR077678 · NIAMS · WASHINGTON UNIVERSITY · PI SETTON, LORI A., TANG, SIMON YUE-CHEONG · 2020 to 2024
$3.7M
The role of physiologic and pathologic AGEs on RAGE signaling in IVD degenerationR01AR074441 · NIAMS · WASHINGTON UNIVERSITY · PI TANG, SIMON YUE-CHEONG · 2019 to 2024
$2.1M
Cabinet microCT System for Musculoskeletal Specimen ImagingS10OD028573 · OD · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2020 to 2020
$407k
The Role of VEGF in the Development of Low Back Pain Following IVD InjuryR21AR081517 · NIAMS · WASHINGTON UNIVERSITY · PI GUPTA, MUNISH, TANG, SIMON YUE-CHEONG · 2023 to 2024
$371k
Effects of Ages and Rage on IVD Degeneration And InflammationR21AR069804 · NIAMS · WASHINGTON UNIVERSITY · PI TANG, SIMON YUE-CHEONG · 2017 to 2018
$369k
NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR074441NIAMS NIH HHS R01 AR077678NIAMS NIH HHS R21 AR069804NIAMS NIH HHS R21 AR081517NIH HHS S10 OD028573
6 · The paper itself

Abstract

There are currently no therapies for the staggering disability and public health costs of chronic low back pain (LBP). Innervation of the degenerating intervertebral disc (IVD) is suspected to cause discogenic LBP, but the mechanisms that orchestrate the IVD's neo-innervation and subsequent symptoms of LBP remain unknown. We hypothesize that Vascular Endothelial Growth Factor-A (VEGFA) critically mediates the neurite invasion in the IVD and contributes to prolonged LBP. Initiating IVD degeneration through a mechanical injury, we evaluated the progression of neurovascular features into the IVD, as well as resultant LBP symptoms and locomotive performance at acute (3-weeks) and prolonged (12-weeks) time points following the IVD injury. To determine the role of VEGFA, we used a mouse model with ubiquitously inducible recombination of the floxed Vegfa allele (UBC-Cre

Indexed as

intervertebral disc injurylow back painneurovascular featurespreclinical modelVEGFA

Identifiers

PMID40501758
PMCPMC12157658

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.