Evidence map›Paper›PMID 40501757›Full record

ArticlebioRxiv : the preprint server for biology2025

Non-invasive measures of DNA methylation capture molecular aging in wild capuchin monkeys.

B Sadoughi, R Hernández-Rojas, H Hamou, R Lopez, M Mah, E Slikas, Smv Simmons, J D Orkin, J P Higham, S F Brosnan and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

B SadoughiCenter for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.ORCID 0000-0001-5626-3318
R Hernández-RojasDepartment of Anthropology and Archaeology, University of Calgary, Calgary, Canada.
H HamouDepartment of Anthropology and Archaeology, University of Calgary, Calgary, Canada.
R LopezSanta Rosa Primate Project, Área de Conservación Guanacaste, Liberia, Costa Rica.
M MahDepartment of Anthropology and Archaeology, University of Calgary, Calgary, Canada.
E SlikasCenter for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.
Smv SimmonsDepartment of Psychology and Language Research Center, Georgia State University, Atlanta, GA USA.
J D OrkinDépartement d'anthropologie, Université de Montréal, Montréal, QC, Canada.
J P HighamDepartment of Anthropology, New York University, New York, NY, USA.
S F BrosnanDepartment of Psychology and Language Research Center, Georgia State University, Atlanta, GA USA.
K M JackDepartment of Anthropology, Tulane University, New Orleans, LA.
F A CamposDepartment of Anthropology, University of Texas at San Antonio, San Antonio, TX, USA.
N Snyder-MacklerCenter for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.ORCID 0000-0003-3026-6160
A D MelinDepartment of Anthropology and Archaeology, University of Calgary, Calgary, Canada.

Funding

A new model system for assessing the socio-environmental determinants of the pace of aging: leveraging a long-term study of wild capuchinsR61AG078529 · NIA · UNIVERSITY OF TEXAS SAN ANTONIO · PI CAMPOS, FERNANDO ALONSO, JACK, KATHARINE MARY · 2022 to 2023
$570k
A new model system for assessing the socio-environmental determinants of the pace of aging: leveraging a long-term study of wild capuchinsR33AG078529 · NIA · UNIVERSITY OF TEXAS SAN ANTONIO · PI Fernando Alonso Campos, Katharine Mary Jack · 2026 to 2026
$197k
NIA NIH HHS R33 AG078529NIA NIH HHS R61 AG078529
6 · The paper itself

Abstract

Elucidating the socio-ecological factors that shape patterns of epigenetic modification in long-lived vertebrates is of broad interest to evolutionary biologists, geroscientists, and ecologists. However, aging research in wild populations is limited due to inability to measure cellular hallmarks of aging noninvasively. Here, we demonstrate that cellular DNA methylation (DNAm) profiles from fecal samples provide an accurate and reliable molecular clock in wild capuchin monkeys. Analysis of blood, feces, and urine samples from a closely related species shows that DNAm differentiates between species and different types of biological samples. We further find age-associated differences in DNAm relevant to cellular damage, inflammation, and senescence, consistent with hallmarks conserved across humans and other mammalian species, speaking to the comparative potential. By demonstrating that DNAm can be studied non-invasively in wild animals, our research opens new avenues in the study of modifiers of the pace of aging, and increases potential for cross-population and species comparisons.

Identifiers

PMID40501757
PMCPMC12157484

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.